Nanofibrous Membrane Dressings Loaded With Sodium Hydrogen Sulfide/Endothelial Progenitor Cells Promote Wound Healing
| العنوان: | Nanofibrous Membrane Dressings Loaded With Sodium Hydrogen Sulfide/Endothelial Progenitor Cells Promote Wound Healing |
|---|---|
| المؤلفون: | Xueyao Cai, Chun Li, Yi Cao, Yuchen Cai, Guanqun Ju, Jie Lian, Sunxiang Ma |
| المصدر: | Frontiers in Bioengineering and Biotechnology, Vol 9 (2021) Frontiers in Bioengineering and Biotechnology |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | sustained-releasing, Histology, H2S, Sodium, Hydrogen sulfide, Regeneration (biology), nanofibrous membrane, Biomedical Engineering, Bioengineering and Biotechnology, chemistry.chemical_element, Bioengineering, wound healing, equipment and supplies, chemistry.chemical_compound, Membrane, chemistry, In vivo, Biophysics, Progenitor cell, Drug carrier, Wound healing, TP248.13-248.65, Original Research, endothelial progenitor cells, Biotechnology |
| الوصف: | Hydrogen sulfide (H2S) has been identified as an important gasotransmitter. H2S donor can release H2S sustained and is used as wound dressing. Endothelial progenitor cells (EPCs), given their regenerative ability, have also been reported to enhance wound healing. However, effective drug carriers are missing for the clinical application of H2S and EPCs. In this study, we investigated a novel drug carrier nanofibrous membrane, which was prepared by blending the recombinant spider silk protein (rMaSp) and sodium hydrogen sulfide (NaHS) by electrospun. Our results show that the rMaSp/NaHS nanofibrous membrane is associated with high hemocompatibility and cytocompatibility and is capable of stably releasing H2S for a long period of time. We also tested the rMaSp/NaHS membrane loaded with EPCs in an in vivo cutaneous wound model. We showed that the rMaSp/NaHS/EPC system significantly enhances wound regeneration efficiency as compared to rMaSp membrane and rMaSp/NaHS membrane. This study provides key evidence supporting the clinical application of nanofibrous membrane in the field of skin tissue regeneration. |
| اللغة: | English |
| تدمد: | 2296-4185 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173faddbd80c484a18fe4d8037c73c03Test https://www.frontiersin.org/articles/10.3389/fbioe.2021.657549/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....173faddbd80c484a18fe4d8037c73c03 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22964185 |
|---|