B7-H3/CD276: An Emerging Cancer Immunotherapy
| العنوان: | B7-H3/CD276: An Emerging Cancer Immunotherapy |
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| المؤلفون: | Wu-Tong Zhou, Weilin Jin |
| المصدر: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, B7 Antigens, medicine.medical_treatment, Immunology, Review, 03 medical and health sciences, 0302 clinical medicine, Immune system, Cancer immunotherapy, Neoplasms, Tumor Microenvironment, Immunology and Allergy, Medicine, Animals, Humans, tumor immunology, immune checkpoint, Tumor microenvironment, cancer immunotherapy, Signal Pathways, business.industry, Cancer, Immunotherapy, B7-H3/CD276, RC581-607, medicine.disease, Immune checkpoint, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Immunologic diseases. Allergy, business |
| الوصف: | Immunotherapy aiming at suppressing tumor development by relying on modifying or strengthening the immune system prevails among cancer treatments and points out a new direction for cancer therapy. B7 homolog 3 protein (B7-H3, also known as CD276), a newly identified immunoregulatory protein member of the B7 family, is an attractive and promising target for cancer immunotherapy because it is overexpressed in tumor tissues while showing limited expression in normal tissues and participating in tumor microenvironment (TME) shaping and development. Thus far, numerous B7-H3-based immunotherapy strategies have demonstrated potent antitumor activity and acceptable safety profiles in preclinical models. Herein, we present the expression and biological function of B7-H3 in distinct cancer and normal cells, as well as B7-H3-mediated signal pathways in cancer cells and B7-H3-based tumor immunotherapy strategies. This review provides a comprehensive overview that encompasses B7-H3’s role in TME to its potential as a target in cancer immunotherapy. |
| اللغة: | English |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c110a533b4361facf49c2c47fe200549Test http://europepmc.org/articles/PMC8326801Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c110a533b4361facf49c2c47fe200549 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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