دورية أكاديمية
Antibodies against the SARS-CoV-2 S1-RBD cross-react with dengue virus and hinder dengue pathogenesis
| العنوان: | Antibodies against the SARS-CoV-2 S1-RBD cross-react with dengue virus and hinder dengue pathogenesis |
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| المؤلفون: | Yi-Ling Cheng, Chiao-Hsuan Chao, Yen-Chung Lai, Kun-Han Hsieh, Jen-Ren Wang, Shu-Wen Wan, Hong-Jyun Huang, Yung-Chun Chuang, Woei-Jer Chuang, Trai-Ming Yeh |
| المصدر: | Frontiers in Immunology, Vol 13 (2022) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | COVID-19, dengue virus, SARS-CoV-2, diagnosis, antibody-dependent enhancement, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally since December 2019. Several studies reported that SARS-CoV-2 infections may produce false-positive reactions in dengue virus (DENV) serology tests and vice versa. However, it remains unclear whether SARS-CoV-2 and DENV cross-reactive antibodies provide cross-protection against each disease or promote disease severity. In this study, we confirmed that antibodies against the SARS-CoV-2 spike protein and its receptor-binding domain (S1-RBD) were significantly increased in dengue patients compared to normal controls. In addition, anti-S1-RBD IgG purified from S1-RBD hyperimmune rabbit sera could cross-react with both DENV envelope protein (E) and nonstructural protein 1 (NS1). The potential epitopes of DENV E and NS1 recognized by these antibodies were identified by a phage-displayed random peptide library. In addition, DENV infection and DENV NS1-induced endothelial hyperpermeability in vitro were inhibited in the presence of anti-S1-RBD IgG. Passive transfer anti-S1-RBD IgG into mice also reduced prolonged bleeding time and decreased NS1 seral level in DENV-infected mice. Lastly, COVID-19 patients’ sera showed neutralizing ability against dengue infection in vitro. Thus, our results suggest that the antigenic cross-reactivity between the SARS-CoV-2 S1-RBD and DENV can induce the production of anti-SARS-CoV-2 S1-RBD antibodies that cross-react with DENV which may hinder dengue pathogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1664-3224 |
| العلاقة: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.941923/fullTest; https://doaj.org/toc/1664-3224Test; https://doaj.org/article/1593d7bfd4814c728ffc08e8dce945ceTest |
| DOI: | 10.3389/fimmu.2022.941923 |
| الإتاحة: | https://doi.org/10.3389/fimmu.2022.941923Test https://doaj.org/article/1593d7bfd4814c728ffc08e8dce945ceTest |
| رقم الانضمام: | edsbas.F9F8A7D1 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16643224 |
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| DOI: | 10.3389/fimmu.2022.941923 |