دورية أكاديمية
Bacterial Signatures of Paediatric Respiratory Disease : An Individual Participant Data Meta-Analysis
| العنوان: | Bacterial Signatures of Paediatric Respiratory Disease : An Individual Participant Data Meta-Analysis |
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| المؤلفون: | Broderick, David T. J., Waite, David W., Marsh, Robyn L., Camargo, Carlos A., Cardenas, Paul, Chang, Anne B., Cookson, William O. C., Cuthbertson, Leah, Dai, Wenkui, Everard, Mark L., Gervaix, Alain, Harris, J. Kirk, Hasegawa, Kohei, Hoffman, Lucas R., Hong, Soo-Jong, Josset, Laurence, Kelly, Matthew S., Kim, Bong-Soo, Kong, Yong, Li, Shuai C., Mansbach, Jonathan M., Mejias, Asuncion, O'Toole, George A., Paalanen, Laura, Perez-Losada, Marcos, Pettigrew, Melinda M., Pichon, Maxime, Ramilo, Octavio, Ruokolainen, Lasse, Sakwinska, Olga, Seed, Patrick C., van der Gast, Christopher J., Wagner, Brandie D., Yi, Hana, Zemanick, Edith T., Zheng, Yuejie, Pillarisetti, Naveen, Taylor, Michael W. |
| المساهمون: | Biosciences, Helsinki Institute of Sustainability Science (HELSUS), Veijo Kaitala / Principal Investigator |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2022 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | microbiota (16S), respiratory tract, respiratory infection, paediatrics, meta-analysis, individual participant data (IPD) meta-analysis, NASOPHARYNGEAL MICROBIOTA, AIRWAY MICROBIOTA, CHILDREN, PNEUMONIA, SEVERITY, 3121 General medicine, internal medicine and other clinical medicine, 11832 Microbiology and virology |
| الوصف: | Introduction: The airway microbiota has been linked to specific paediatric respiratory diseases, but studies are often small. It remains unclear whether particular bacteria are associated with a given disease, or if a more general, non-specific microbiota association with disease exists, as suggested for the gut. We investigated overarching patterns of bacterial association with acute and chronic paediatric respiratory disease in an individual participant data (IPD) meta-analysis of 16S rRNA gene sequences from published respiratory microbiota studies.Methods: We obtained raw microbiota data from public repositories or via communication with corresponding authors. Cross-sectional analyses of the paediatric (10 case subjects were included. Sequence data were processed using a uniform bioinformatics pipeline, removing a potentially substantial source of variation. Microbiota differences across diagnoses were assessed using alpha- and beta-diversity approaches, machine learning, and biomarker analyses.Results: We ultimately included 20 studies containing individual data from 2624 children. Disease was associated with lower bacterial diversity in nasal and lower airway samples and higher relative abundances of specific nasal taxa including Streptococcus and Haemophilus. Machine learning success in assigning samples to diagnostic groupings varied with anatomical site, with positive predictive value and sensitivity ranging from 43 to 100 and 8 to 99%, respectively.Conclusion: IPD meta-analysis of the respiratory microbiota across multiple diseases allowed identification of a non-specific disease association which cannot be recognised by studying a single disease. Whilst imperfect, machine learning offers promise as a potential additional tool to aid clinical diagnosis. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-00-744731-2 0-00-744731-0 |
| العلاقة: | Broderick , D T J , Waite , D W , Marsh , R L , Camargo , C A , Cardenas , P , Chang , A B , Cookson , W O C , Cuthbertson , L , Dai , W , Everard , M L , Gervaix , A , Harris , J K , Hasegawa , K , Hoffman , L R , Hong , S-J , Josset , L , Kelly , M S , Kim , B-S , Kong , Y , Li , S C , Mansbach , J M , Mejias , A , O'Toole , G A , Paalanen , L , Perez-Losada , M , Pettigrew , M M , Pichon , M , Ramilo , O , Ruokolainen , L , Sakwinska , O , Seed , P C , van der Gast , C J , Wagner , B D , Yi , H , Zemanick , E T , Zheng , Y , Pillarisetti , N & Taylor , M W 2021 , ' Bacterial Signatures of Paediatric Respiratory Disease : An Individual Participant Data Meta-Analysis ' , Frontiers in Microbiology , vol. 12 , 711134 . https://doi.org/10.3389/fmicb.2021.711134Test; ORCID: /0000-0003-0951-9100/work/108865891; 921eb45f-c1bf-4c6d-ba12-3a4bcd6aab98; http://hdl.handle.net/10138/340731Test; 000744731000001 |
| الإتاحة: | http://hdl.handle.net/10138/340731Test |
| حقوق: | cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.40990C13 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780007447312 0007447310 |
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