دورية أكاديمية
Translation of in vitro -transcribed RNA therapeutics
| العنوان: | Translation of in vitro -transcribed RNA therapeutics |
|---|---|
| المؤلفون: | von der Haar, Tobias, Mulroney, Thomas E., Hedayioglu, Fabio, Kurusamy, Sathishkuma, Rust, Maria, Lilley, Kathryn S., Thaventhiran, James E., Willis, Anne E., Smales, C. Mark |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2023 |
| المجموعة: | University of Kent: KAR - Kent Academic Repository |
| مصطلحات موضوعية: | Q Science, QH Natural history, QH301 Biology |
| الوصف: | In vitro transcribed, modified messenger RNAs (IVTmRNAs) have been used to vaccinate billions of individuals against the SARS-CoV-2 virus, and are currently being developed for many additional therapeutic applications. IVTmRNAs must be translated into proteins with therapeutic activity by the same cellular machinery that also translates native endogenous transcripts. However, different genesis pathways and routes of entry into target cells as well as the presence of modified nucleotides mean that the way in which IVTmRNAs engage with the translational machinery, and the efficiency with which they are being translated, differs from native mRNAs. This review summarises our current knowledge of commonalities and differences in translation between IVTmRNAs and cellular mRNAs, which is key for the development of future design strategies that can generate IVTmRNAs with improved activity in therapeutic applications. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://kar.kent.ac.uk/100172/1/fmolb-10-1128067.pdfTest; von der Haar, Tobias, Mulroney, Thomas E., Hedayioglu, Fabio, Kurusamy, Sathishkuma, Rust, Maria, Lilley, Kathryn S., Thaventhiran, James E., Willis, Anne E., Smales, C. Mark (2023) Translation of in vitro -transcribed RNA therapeutics. Frontiers in Molecular Biosciences, 10 . Article Number 1128067. ISSN 2296-889X. (doi:10.3389/fmolb.2023.1128067 ) (KAR id:100172 ) |
| DOI: | 10.3389/fmolb.2023.1128067 |
| الإتاحة: | https://doi.org/10.3389/fmolb.2023.1128067Test https://kar.kent.ac.uk/100172Test/ https://kar.kent.ac.uk/100172/1/fmolb-10-1128067.pdfTest |
| حقوق: | cc_by |
| رقم الانضمام: | edsbas.C5ED2878 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fmolb.2023.1128067 |
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