Membrane lipid unsaturation as physiological adaptation to animal longevity
| العنوان: | Membrane lipid unsaturation as physiological adaptation to animal longevity |
|---|---|
| المؤلفون: | Alba Naudí, Victoria Ayala, Mariona Jové, Manuel Portero-Otin, Reinald Pamplona, Gustavo Barja |
| المصدر: | Recercat. Dipósit de la Recerca de Catalunya instname Frontiers in Physiology, Vol 4 (2013) Frontiers in Physiology Repositorio Abierto de la UdL Universitad de Lleida |
| بيانات النشر: | Frontiers Media |
| مصطلحات موضوعية: | Antioxidant, Physiology, fatty acid biosynthesis, media_common.quotation_subject, medicine.medical_treatment, Oxidative phosphorylation, Review Article, Biology, medicine.disease_cause, lcsh:Physiology, Physiology (medical), Oxidative damage, medicine, rate of aging, peroxidizability index, media_common, fatty acid synthesis, Genetics, membrane unsaturation, lcsh:QP1-981, Mechanism (biology), Longevity, Biological membrane, Fatty acid biosynthesis, Cell biology, phylogenomic analysis, Membrane, Adaptation, Oxidative stress, Reactive carbonyl species, Membrane unsaturation |
| الوصف: | The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and functional systems. The evolution of using oxygen for efficient energy production served as a driving force for the evolution of complex organisms. The redox reactions associated with its use were, however, responsible for the production of reactive species (derived from oxygen and lipids) with damaging effects due to oxidative chemical modifications of essential cellular components. Consequently, aerobic life required the emergence and selection of antioxidant defense systems. As a result, a high diversity in molecular and structural antioxidant defenses evolved. In the following paragraphs, we analyze the adaptation of biological membranes as a dynamic structural defense against reactive species evolved by animals. In particular, our goal is to describe the physiological mechanisms underlying the structural adaptation of cellular membranes to oxidative stress and to explain the meaning of this adaptive mechanism, and to review the state of the art about the link between membrane composition and longevity of animal species. Investigations of the author of this review have been supported in part by I+D grants from the Spanish Ministry of Science and Innovation (BFU2011-23888), and BSCH-UCM (2009-2010) to Gustavo Barja; and grants from the Spanish Ministry of Education and Science (BFU2009-11879/BFI), the Spanish Ministry of Economy and Competitiveness-Institute of Health Carlos III (PI13/00584) and the Generalitat of Catalunya (2009SGR735) to Reinald Pamplona. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9924c5a3e3bda841c9d580203fed53d7Test http://hdl.handle.net/10459.1/56685Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9924c5a3e3bda841c9d580203fed53d7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |