دورية أكاديمية
Results of haploidentical transplant in patients with donor-specific antibodies: a survey on behalf of the Spanish Group of Hematopoietic Transplant and Cell Therapy
| العنوان: | Results of haploidentical transplant in patients with donor-specific antibodies: a survey on behalf of the Spanish Group of Hematopoietic Transplant and Cell Therapy |
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| المؤلفون: | Bailén, Rebeca, Alenda, Raquel, Herruzo-Delgado, Beatriz, Acosta-Fleitas, Cynthia, Vallés, Ana, Esquirol, Albert, Fonseca, Marta, Solán, Laura, Sánchez-Vadillo, Irene, Bautista, Guiomar, Bento, Leyre, López-Godino, Oriana, Pérez-Martínez, Ariadna, Torrent, Anna, Zanabili, Joud, Calbacho, María, Moreno, Miguel Ángel, Pascual-Cascón, María Jesús, Guerra-Domínguez, Luisa, Chinea, Anabelle, García-Cadenas, Irene, López-Corral, L., Boix, Francisco, López Lorenzo, José Luis, Humala, Karem, Duarte, Rafael, Sampol, Antonia, Heras, Inmaculada, Vicario, José Luis, Balas, Antonio, Oarbeascoa, Gillen, Fernández-Caldas, Paula, Anguita, Javier, Kwon, Mi |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2023 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Donor-specific antibodies, Graft failure, Haplo-HSCT, Desensitization strategies, DSA kinetics |
| الوصف: | [Background]: Donor-specific antibodies (DSAs) are IgG allo-antibodies against mismatched donor HLA molecules and can cause graft failure (GF) in the setting of haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Our aim was to report the experience of the Spanish Group of Hematopoietic Transplant (GETH-TC) in DSA-positive patients who had undergone haplo-HSCT. ; [Methods]: We conducted a survey of patients who underwent haplo-HSCT in GETH-TC centers between 2012 and 2021. Data were collected on the DSA assay used, monitoring strategy, complement fixation, criteria for desensitization, desensitization strategies and transplant outcomes. ; [Results]: Fifteen centers from the GETH-TC responded to the survey. During the study period, 1,454 patients underwent haplo-HSCT. Seventy of the transplants were performed in 69 DSA-positive patients, all of whom lacked a suitable alternative donor; 61 (88%) patients were female (90% with prior pregnancies). All patients received post-transplant cyclophosphamide-based graft-versus-host disease prophylaxis. Regarding baseline DSA intensity, 46 (67%) patients presented mean fluorescence intensity (MFI) >5,000, including 21 (30%) with MFI >10,000 and three (4%) with MFI >20,000. Six patients did not receive desensitization treatment, four of them with MFI <5,000. Of 63 patients receiving desensitization treatment, 48 (76%) were tested after desensitization therapy, and a reduction in intensity was confirmed in 45 (71%). Three patients (5%) experienced an increase in MFI after desensitization, two of whom experienced primary GF. Cumulative incidence of neutrophil engraftment at day 28 was 74% in a median of 18 days (IQR, 15─20); six patients died before engraftment due to toxicity or infection and eight patients had primary GF despite desensitization in seven of them. After a median follow-up of 30 months, two-year overall and event-free survival were 46.5% and 39%, respectively. The two-year cumulative incidence of relapse was 16% and non-relapse ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-3224 |
| العلاقة: | Frontiers in immunology; Publisher's version; The underlying dataset has been published as supplementary material of the article in the publisher platform at 10.3389/fimmu.2023.1165759; https://doi.org/10.3389/fimmu.2023.1165759Test; Sí; Frontiers in Immunology 14: 1165759 (2023); http://hdl.handle.net/10261/352671Test; 2-s2.0-85161674218; https://api.elsevier.com/content/abstract/scopus_id/85161674218Test |
| DOI: | 10.3389/fimmu.2023.1165759 |
| الإتاحة: | https://doi.org/10.3389/fimmu.2023.1165759Test http://hdl.handle.net/10261/352671Test https://api.elsevier.com/content/abstract/scopus_id/85161674218Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.BCE5368 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16643224 |
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| DOI: | 10.3389/fimmu.2023.1165759 |