دورية أكاديمية
Age-Adjusted Endothelial Activation and Stress Index for Coronavirus Disease 2019 at Admission Is a Reliable Predictor for 28-Day Mortality in Hospitalized Patients With Coronavirus Disease 2019
| العنوان: | Age-Adjusted Endothelial Activation and Stress Index for Coronavirus Disease 2019 at Admission Is a Reliable Predictor for 28-Day Mortality in Hospitalized Patients With Coronavirus Disease 2019 |
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| المؤلفون: | Pérez-García, Felipe, Bailén, Rebeca, Torres-Macho, Juan, Fernandez-Rodriguez, Amanda, Jimenez-Sousa, Maria Angeles, Jiménez, Eva, Pérez-Butragueño, Mario, Cuadros-González, Juan, Cadiñanos, Julen, García-García, Irene, Ryan, Pablo, Resino, Salvador |
| المساهمون: | Instituto de Salud Carlos III |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2021 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | COVID-19, Blood coagulation disorders, Clinical prediction rule, Endothelium, Mortality |
| الوصف: | Background: Endothelial Activation and Stress Index (EASIX) predict death in patients undergoing allogeneic hematopoietic stem cell transplantation who develop endothelial complications. Because coronavirus disease 2019 (COVID-19) patients also have coagulopathy and endotheliitis, we aimed to assess whether EASIX predicts death within 28 days in hospitalized COVID-19 patients. Methods: We performed a retrospective study on COVID-19 patients from two different cohorts [derivation (n = 1,200 patients) and validation (n = 1,830 patients)]. The endpoint was death within 28 days. The main factors were EASIX [(lactate dehydrogenase * creatinine)/thrombocytes] and aEASIX-COVID (EASIX * age), which were log2-transformed for analysis. Results: Log2-EASIX and log2-aEASIX-COVID were independently associated with an increased risk of death in both cohorts (p < 0.001). Log2-aEASIX-COVID showed a good predictive performance for 28-day mortality both in the derivation cohort (area under the receiver-operating characteristic = 0.827) and in the validation cohort (area under the receiver-operating characteristic = 0.820), with better predictive performance than log2-EASIX (p < 0.001). For log2 aEASIX-COVID, patients with low/moderate risk (<6) had a 28-day mortality probability of 5.3% [95% confidence interval (95% CI) = 4-6.5%], high (6-7) of 17.2% (95% CI = 14.7-19.6%), and very high (>7) of 47.6% (95% CI = 44.2-50.9%). The cutoff of log2 aEASIX-COVID = 6 showed a positive predictive value of 31.7% and negative predictive value of 94.7%, and log2 aEASIX-COVID = 7 showed a positive predictive value of 47.6% and negative predictive value of 89.8%. Conclusion: Both EASIX and aEASIX-COVID were associated with death within 28 days in hospitalized COVID-19 patients. However, aEASIX-COVID had significantly better predictive performance than EASIX, particularly for discarding death. Thus, aEASIX-COVID could be a reliable predictor of death that could help to manage COVID-19 patients. ; This study was supported by grants ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2296-858X |
| العلاقة: | Publisher's version; https://doi.org/10.3389/fmed.2021.736028Test; info:eu-repo/grantAgreement/ES/COV20/1144; info:eu-repo/grantAgreement/ES/MPY224/20; info:eu-repo/grantAgreement/ES/CP17CIII/00007; info:eu-repo/grantAgreement/ES/CP14CIII/00010; Front Med (Lausanne). 2021;8:736028.; http://hdl.handle.net/20.500.12105/14238Test; Frontiers in Medicine |
| DOI: | 10.3389/fmed.2021.736028 |
| الإتاحة: | https://doi.org/20.500.12105/14238Test https://doi.org/10.3389/fmed.2021.736028Test https://hdl.handle.net/20.500.12105/14238Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; Atribución 4.0 Internacional ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AC375721 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2296858X |
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| DOI: | 10.3389/fmed.2021.736028 |