Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota
| العنوان: | Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota |
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| المؤلفون: | Elisabetta Manuali, Claudia Pistoia, Rosanna Drumo, Michela Tarantino, Paolo Pasquali, Matteo Picciolini, Paola Petrucci, Michele Pesciaroli, Gianfranco Gabai, Giovanni Loris Alborali, Valerio Napolioni, Silvia Pavone, Livia Moscati, Chiara Francesca Magistrali, Barbara Chirullo, Nicola Martinelli, Jessica Ruggeri, Andrea Battistoni, Serena Ammendola, Giovanni Pezzotti |
| المصدر: | E-Prints Complutense. Archivo Institucional de la UCM instname Frontiers in Cellular and Infection Microbiology Frontiers in Cellular and Infection Microbiology, Vol 5 (2016) E-Prints Complutense: Archivo Institucional de la UCM Universidad Complutense de Madrid |
| بيانات النشر: | Frontiers Media, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | 0301 basic medicine, pig, Microbiology (medical), Salmonella, salmonellosis, Swine, 030106 microbiology, Immunology, lcsh:QR1-502, Virulence, Colonisation resistance, medicine.disease_cause, Microbiology, lcsh:Microbiology, immune response, 03 medical and health sciences, Immune system, Antibiosis, medicine, microbiota, Animals, Colonization, Settore BIO/10, Pathogen, Original Research, Salmonella Infections, Animal, biology, Animal, Wild type, biology.organism_classification, Newborn, Gastrointestinal Microbiome, 030104 developmental biology, Infectious Diseases, Animals, Newborn, Salmonella enterica, inflammation, Salmonella Infections, Salmonella Typhimurium, Veterinaria, Immune response, Inflammation, Microbiota, Pig, Salmonellosis, Salmonella typhimurium |
| الوصف: | Salmonella enterica serovar Typhimurium is an important zoonotic gastrointestinal pathogen responsible for foodborne disease worldwide. It is a successful enteric pathogen because it has developed virulence strategies allowing it to survive in a highly inflamed intestinal environment exploiting inflammation to overcome colonization resistance provided by intestinal microbiota. In this study, we used piglets featuring an intact microbiota, which naturally develop gastroenteritis, as model for salmonellosis. We compared the effects on the intestinal microbiota induced by a wild type and an attenuated S. Typhimurium in order to evaluate whether the modifications are correlated with the virulence of the strain. This study showed that Salmonella alters microbiota in a virulence-dependent manner. We found that the wild type S. Typhimurium induced inflammation and a reduction of specific protecting microbiota species (SCFA-producing bacteria) normally involved in providing a barrier against pathogens. Both these effects could contribute to impair colonization resistance, increasing the host susceptibility to wild type S. Typhimurium colonization. In contrast, the attenuated S. Typhimurium, which is characterized by a reduced ability to colonize the intestine, and by a very mild inflammatory response, was unable to successfully sustain competition with the microbiota. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493bb598e0cdadb026c4653c34f789bcTest http://eprints.ucm.es/39610Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....493bb598e0cdadb026c4653c34f789bc |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |