دورية أكاديمية
Shared PKS Module in Biosynthesis of Synergistic Laxaphycins
| العنوان: | Shared PKS Module in Biosynthesis of Synergistic Laxaphycins |
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| المؤلفون: | Heinilä, Lassi, Fewer, David, Jokela, Jouni, Wahlsten, Matti, Jortikka, Anna Elisabeth, Sivonen, Kaarina |
| المساهمون: | Department of Microbiology, Cyanobacteria research, Helsinki Institute of Sustainability Science (HELSUS), Microbial Natural Products, Department of Food and Nutrition, Faculty of Agriculture and Forestry |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2020 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | 11832 Microbiology and virology, Synergy, Biosynthesis, Dehydrobutyrine, Natural Product, Cupin, Laxaphycin, Scytocyclamide, Antifungal, NONRIBOSOMAL PEPTIDE SYNTHETASES, ANTIFUNGAL CYCLIC-PEPTIDES, ALGA ANABAENA-LAXA, GENE-CLUSTER, NATURAL-PRODUCTS, CYANOBACTERIA, LIPOPEPTIDES, ANABAENOPEPTIN, TRICHORMAMIDES, IDENTIFICATION |
| الوصف: | Cyanobacteria produce a wide range of lipopeptides that exhibit potent membrane-disrupting activities. Laxaphycins consist of two families of structurally distinct macrocyclic lipopeptides that act in a synergistic manner to produce antifungal and antiproliferative activities. Laxaphycins are produced by range of cyanobacteria but their biosynthetic origins remain unclear. Here, we identified the biosynthetic pathways responsible for the biosynthesis of the laxaphycins produced by Scytonema hofmannii PCC 7110. We show that these laxaphycins, called scytocyclamides, are produced by this cyanobacterium and are encoded in a single biosynthetic gene cluster with shared polyketide synthase enzymes initiating two distinct non-ribosomal peptide synthetase pathways. The unusual mechanism of shared enzymes synthesizing two distinct types of products may aid future research in identifying and expressing natural product biosynthetic pathways and in expanding the known biosynthetic logic of this important family of natural products. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-00-576262-2 0-00-576262-6 |
| العلاقة: | Heinilä , L , Fewer , D , Jokela , J , Wahlsten , M , Jortikka , A E & Sivonen , K 2020 , ' Shared PKS Module in Biosynthesis of Synergistic Laxaphycins ' , Frontiers in Microbiology , vol. 11 , 578878 . https://doi.org/10.3389/fmicb.2020.578878Test; ORCID: /0000-0003-3978-4845/work/82465238; ORCID: /0000-0001-5096-3575/work/82466657; ORCID: /0000-0002-2904-0458/work/82466746; ORCID: /0000-0002-4107-1695/work/82467178; ORCID: /0000-0003-2558-0091/work/82469670; 3448b5b9-79d9-4e74-aa15-503dbc7e5b90; http://hdl.handle.net/10138/320549Test; 000576262600001 |
| الإتاحة: | http://hdl.handle.net/10138/320549Test |
| حقوق: | cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8DC73328 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780005762622 0005762626 |
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