Aging in a Relativistic Biological Space-Time
| العنوان: | Aging in a Relativistic Biological Space-Time |
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| المؤلفون: | Davide Maestrini, Daniel Abler, Vikram Adhikarla, Saro Armenian, Sergio Branciamore, Nadia Carlesso, Ya-Huei Kuo, Guido Marcucci, Prativa Sahoo, Russell C. Rockne |
| المصدر: | Maestrini, Davide; Abler, Daniel; Adhikarla, Vikram; Armenian, Saro; Branciamore, Sergio; Carlesso, Nadia; Kuo, Ya-Huei; Marcucci, Guido; Sahoo, Prativa; Rockne, Russell C. (2018). Aging in a Relativistic Biological Space-Time. Frontiers in cell and developmental biology, 6(55), p. 55. Frontiers 10.3389/fcell.2018.00055 <http://dx.doi.org/10.3389/fcell.2018.00055Test> Frontiers in Cell and Developmental Biology Frontiers in Cell and Developmental Biology, Vol 6 (2018) |
| بيانات النشر: | Frontiers, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Biological clock, Computer science, time-contraction, 610 Medicine & health, Cell and Developmental Biology, 03 medical and health sciences, 0302 clinical medicine, 510 Mathematics, Hypothesis and Theory, biological space-time, Time dilation, Cancer biology, lcsh:QH301-705.5, Contraction (operator theory), 030304 developmental biology, Cognitive science, 0303 health sciences, special relativity, Space time, aging, Cell Biology, manifolds, 030104 developmental biology, lcsh:Biology (General), 030220 oncology & carcinogenesis, Physical space, 570 Life sciences, biology, biological clocks, Developmental Biology |
| الوصف: | Here we present a theoretical and mathematical perspective on the process of aging. We extend the concepts of physical space and time to an abstract, mathematically-defined space, which we associate with a concept of “biological space-time” in which biological dynamics may be represented. We hypothesize that biological dynamics, represented as trajectories in biological space-time, may be used to model and study different rates of biological aging. As a consequence of this hypothesis, we show how dilation or contraction of time analogous to relativistic corrections of physical time resulting from accelerated or decelerated biological dynamics may be used to study precipitous or protracted aging. We show specific examples of how these principles may be used to model different rates of aging, with an emphasis on cancer in aging. We discuss how this theory may be tested or falsified, as well as novel concepts and implications of this theory that may improve our interpretation of biological aging. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.7892/boris.126758 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e2a867f8a29d3c3ddb354e4adb91a3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....16e2a867f8a29d3c3ddb354e4adb91a3 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.7892/boris.126758 |
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