دورية أكاديمية
Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling
| العنوان: | Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling |
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| المؤلفون: | Bhardwaj, Deepshikha, Nàger Grifo, Mireia, Camats, Judith, David, Mónica Delia, Benguria, Alberto, Dopazo, Ana, Cantí Nicolás, Carles, Herreros Danés, Judit |
| بيانات النشر: | Frontiers |
| سنة النشر: | 2014 |
| المجموعة: | Universitat de Lleida: Repositori Obert UdL |
| مصطلحات موضوعية: | Beta-catenin, Axon, Neurite outgrowth, Chemokine, Sistema nerviós, Axons |
| الوصف: | Axon morphogenesis is a complex process regulated by a variety of secreted molecules, including morphogens and growth factors, resulting in the establishment of the neuronal circuitry. Our previous work demonstrated that growth factors [Neurotrophins (NT) and Hepatocyte Growth Factor (HGF)] signal through β-catenin during axon morphogenesis. HGF signaling promotes axon outgrowth and branching by inducing β-catenin phosphorylation at Y142 and transcriptional regulation of T-Cell Factor (TCF) target genes. Here, we asked which genes are regulated by HGF signaling during axon morphogenesis. An array screening indicated that HGF signaling elevates the expression of chemokines of the CC and CXC families. In line with this, CCL7, CCL20, and CXCL2 significantly increase axon outgrowth in hippocampal neurons. Experiments using blocking antibodies and chemokine receptor antagonists demonstrate that chemokines act downstream of HGF signaling during axon morphogenesis. In addition, qPCR data demonstrates that CXCL2 and CCL5 expression is stimulated by HGF through Met/b-catenin/TCF pathway. These results identify CC family members and CXCL2 chemokines as novel regulators of axon morphogenesis downstream of HGF signaling. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1662-5102 |
| العلاقة: | Reproducció del document publicat a: https://doi.org/10.3389/fncel.2013.00052Test; Frontiers In Cellular Neuroscience, 2013, vol. 7, núm. 52, p. 1-10; http://hdl.handle.net/10459.1/47366Test; https://doi.org/10.3389/fncel.2013.00052Test |
| DOI: | 10.3389/fncel.2013.00052 |
| الإتاحة: | https://doi.org/10.3389/fncel.2013.00052Test http://hdl.handle.net/10459.1/47366Test |
| حقوق: | cc-by, (c) Bhardwaj et al., 2013 ; http://creativecommons.org/licenses/by/3.0/esTest/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.25EB77A9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16625102 |
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| DOI: | 10.3389/fncel.2013.00052 |