Zebrafish Models for Human Skeletal Disorders
| العنوان: | Zebrafish Models for Human Skeletal Disorders |
|---|---|
| المؤلفون: | Mari-Beffa, Manuel, Mesa-Roman, Ana B. B., Duran, Ivan |
| المساهمون: | [Marí-Beffa,M, Mesa-Román,AB, Duran,I] Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, University of Málaga, IBIMA, Málaga, Spain. [Marí-Beffa,M, Duran,I] Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Andalusian Centre for Nanomedicine and Biotechnology-BIONAND, Málaga, Spain., This research is supported by grants PIGE-0178-2020, PID2020-117255RB-100, UMA18-FEDERJA-177, UMA18-FEDERJA-274, and CV20-81404 from Junta de Andalucía and the support of the Fundación AHUCE through a funding contract for OI research., [Mari-Beffa, Manuel] Univ Malaga, Fac Sci, IBIMA, Dept Cell Biol Genet & Physiol, Malaga, Spain, [Mesa-Roman, Ana B. B.] Univ Malaga, Fac Sci, IBIMA, Dept Cell Biol Genet & Physiol, Malaga, Spain, [Duran, Ivan] Univ Malaga, Fac Sci, IBIMA, Dept Cell Biol Genet & Physiol, Malaga, Spain, [Mari-Beffa, Manuel] Andalusian Ctr Nanomed & Biotechnol BIONAND, Networking Biomed Res Ctr Bioengn Biomat & Nanome, Malaga, Spain, [Duran, Ivan] Andalusian Ctr Nanomed & Biotechnol BIONAND, Networking Biomed Res Ctr Bioengn Biomat & Nanome, Malaga, Spain, Junta de Andalucia, Fundacion AHUCE |
| بيانات النشر: | Frontiers, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Candidate gene, Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings], Cilia function, Dwarfisms, Pez cebra, Dentinogénesis imperfecta, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Rare Diseases [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Exome [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Intraflagellar transport protein, Diseases::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Genetic Diseases, Inborn::Dwarfism::Achondroplasia [Medical Subject Headings], Bone-formation, Ciliopatías, Functional-characterization, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Zebrafish models, Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Diseases, Developmental::Osteochondrodysplasias::Osteosclerosis::Osteopetrosis [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Fishes::Cypriniformes::Cyprinidae::Zebrafish [Medical Subject Headings], Skeletal ciliopathies, Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics [Medical Subject Headings], Targeted gene disruption, Natural-history, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies::Genome-Wide Association Study [Medical Subject Headings], Anatomy::Cells::Connective Tissue Cells::Macrophages::Osteoclasts [Medical Subject Headings], Disostosis, Modelos animales, Dysostosis, Osteopetrosis, Acrocefalosindactilia, Skeletal dysplasia, Osteoporosis, Osteogenesis imperfecta, Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings], Induced osteoporosis, Developmental defects |
| الوصف: | In 2019, the Nosology Committee of the International Skeletal Dysplasia Society provided an updated version of the Nosology and Classification of Genetic Skeletal Disorders. This is a reference list of recognized diseases in humans and their causal genes published to help clinician diagnosis and scientific research advances. Complementary to mammalian models, zebrafish has emerged as an interesting species to evaluate chemical treatments against these human skeletal disorders. Due to its versatility and the low cost of experiments, more than 80 models are currently available. In this article, we review the state-of-art of this "aquarium to bedside" approach describing the models according to the list provided by the Nosology Committee. With this, we intend to stimulate research in the appropriate direction to efficiently meet the actual needs of clinicians under the scope of the Nosology Committee. Yes |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5cbf1b7f65cf8f89c3446e46fadc83ccTest https://hdl.handle.net/10668/4068Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..5cbf1b7f65cf8f89c3446e46fadc83cc |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |