دورية أكاديمية
Multiomics insights on the onset, progression, and metastatic evolution of breast cancer
| العنوان: | Multiomics insights on the onset, progression, and metastatic evolution of breast cancer |
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| المؤلفون: | Alvarez-Frutos, Lucia, Barriuso, Daniel, Duran, Mercedes, Infante, Mar, Kroemer, Guido, Palacios-Ramirez, Roberto, Senovilla, Laura |
| بيانات النشر: | Frontiers |
| سنة النشر: | 2023 |
| المجموعة: | UVaDOC - Repositorio Documental de la Universidad de Valladolid |
| مصطلحات موضوعية: | biomarkers, breast cancer, cancer progression, early-stage, metastasis, omics |
| الوصف: | Producción Científica ; Breast cancer is the most common malignant neoplasm in women. Despite progress to date, 700,000 women worldwide died of this disease in 2020. Apparently, the prognostic markers currently used in the clinic are not sufficient to determine the most appropriate treatment. For this reason, great efforts have been made in recent years to identify new molecular biomarkers that will allow more precise and personalized therapeutic decisions in both primary and recurrent breast cancers. These molecular biomarkers include genetic and post-transcriptional alterations, changes in protein expression, as well as metabolic, immunological or microbial changes identified by multiple omics technologies (e.g., genomics, epigenomics, transcriptomics, proteomics, glycomics, metabolomics, lipidomics, immunomics and microbiomics). This review summarizes studies based on omics analysis that have identified new biomarkers for diagnosis, patient stratification, differentiation between stages of tumor development (initiation, progression, and metastasis/recurrence), and their relevance for treatment selection. Furthermore, this review highlights the importance of clinical trials based on multiomics studies and the need to advance in this direction in order to establish personalized therapies and prolong disease-free survival of these patients in the future. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Spanish; Castilian |
| تدمد: | 2234-943X |
| العلاقة: | https://doi.org/10.3389/fonc.2023.1292046Test; Front Oncol. 2023 Dec 19:13:1292046; https://uvadoc.uva.es/handle/10324/66270Test; Frontiers in Oncology; 13 |
| DOI: | 10.3389/fonc.2023.1292046 |
| الإتاحة: | https://doi.org/10.3389/fonc.2023.1292046Test https://uvadoc.uva.es/handle/10324/66270Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.685D669B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2234943X |
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| DOI: | 10.3389/fonc.2023.1292046 |