دورية أكاديمية
Effects of phenylalanine, histidine, and leucine on basal and GHRH-stimulated GH secretion and on PRL, insulin, and glucose levels in short children, comparison with the effects of arginine
| العنوان: | Effects of phenylalanine, histidine, and leucine on basal and GHRH-stimulated GH secretion and on PRL, insulin, and glucose levels in short children, comparison with the effects of arginine |
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| المؤلفون: | J. Bellone, M. R. Valetto, G. Aimaretti, C. Volta, G. Cardimale, C. Baffoni, S. Bernasconi, E. Bartolotta, M. Mucci, E. Ghigo, SEGNI, Maria, PASQUINO, Anna Maria |
| المساهمون: | J., Bellone, M. R., Valetto, G., Aimaretti, Segni, Maria, C., Volta, G., Cardimale, C., Baffoni, Pasquino, Anna Maria, S., Bernasconi, E., Bartolotta, M., Mucci, E., Ghigo |
| بيانات النشر: | FREUND PUBLISHING HOUSE |
| سنة النشر: | 1996 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | arginine, gh, glucose, histidine, insulin, leucine, phenylalanine, prl |
| الوصف: | Of the amino acids arginine is the most potent GH secretagogue in man, It potentiates the GH response to GBRH, exerts a weaker PRL-releasing effect, stimulates insulin and glucagon and induces a biphasic glucose variation, The potency and effects of other amino acids on pituitary and pancreatic hormones need to be clarified, In 43 children with normal short stature (5.3-14.0 yr; 30 M and 13 F) the effects of the infusion of phenylalanine (Phe, 0.08 g/kg), histidine (His, 0.1 g/kg), and leucine (Leu, 0.08 g/kg) on basal and GHRH-stimulated GH secretion and on PRL, insulin and glucose levels were studied and compared with those of arginine at high (hArg, 0.5 g/kg) or low dose (lArg, 0.2 g/kg), Phe increased basal (p<0.05) but not GHRH-stimulated GH levels, induced PRL and insulin rises (p<0.03 and p<0.03), and did not change glycemia, Though a trend toward an increase in basal GH levels was found after His, His and Leu did not significantly modify either basal or GHRH-induced GH secretion nor basal PRL, insulin and glucose levels, Both hArg and lArg increased basal (p<0.0001 and p<0.05, respectively) and GHRH-stimulated GH levels (p<0.006 and p<0.006), hArg increased both PRL (p<0.002) and insulin levels (p<0.005) more (p<0.0005 and p<0.004) than lArg (p<0.005 and p<0.005), while glucose levels showed a similar increase followed by a similar decrease, We conclude that in childhood: a) Phe significantly increases GH secretion but, differently from Arg, does not potentiate the response to GBRH, suggesting different mechanisms of action of these amino acids; b) differently from His and Leu, Phe is a PRL and insulin secretagogue but is less potent than Arg; c) Arg has the highest stimulatory effect on pituitary and pancreatic hormones. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/8961128; info:eu-repo/semantics/altIdentifier/wos/WOS:A1996VX28600004; ispartofbook:Journal of pediatric endocrinology & metabolism : JPEM; volume:9; issue:5; firstpage:523; lastpage:531; numberofpages:9; journal:JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM; http://hdl.handle.net/11573/459018Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-10544251059; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1996VX28600004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest; http://www.scopus.com/inward/record.url?eid=2-s2.0-10544251059&partnerID=65&md5=abcf5540144073756b44aa76e81c53e4Test |
| الإتاحة: | http://hdl.handle.net/11573/459018Test http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=A1996VX28600004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest http://www.scopus.com/inward/record.url?eid=2-s2.0-10544251059&partnerID=65&md5=abcf5540144073756b44aa76e81c53e4Test |
| رقم الانضمام: | edsbas.A6B31F90 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |