Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections
| العنوان: | Host Genetic Background Strongly Influences the Response to Influenza A Virus Infections |
|---|---|
| المؤلفون: | Robert Geffers, Achim D. Gruber, Dunja Bruder, Barkha Srivastava, Paulina Blazejewska, Manuela Heßmann, Klaus Schughart, Susanne Mauel |
| المساهمون: | Department of Experimental Mouse Genetics, Helmholtz Centre for Infection Research & University of Veterinary Medicine Hannover, Braunschweig, Germany. |
| المصدر: | PLoS ONE, Vol 4, Iss 3, p e4857 (2009) PLoS ONE |
| بيانات النشر: | Freie Universität Berlin, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | viruses, Immunology/Innate Immunity, lcsh:Medicine, Virulence, Bronchi, Mice, Inbred Strains, Biology, medicine.disease_cause, Virus, Microbiology, Mice, Influenza A Virus, H1N1 Subtype, Immune system, Orthomyxoviridae Infections, Species Specificity, Influenza A virus, medicine, Animals, lcsh:Science, Pathogen, Multidisciplinary, Host (biology), Genetics and Genomics/Functional Genomics, Infectious Diseases/Respiratory Infections, lcsh:R, virus diseases, Genetics and Genomics/Gene Expression, Epithelial Cells, Viral Load, Virology, Influenza A virus subtype H5N1, Genetics and Genomics/Disease Models, Immunology/Immune Response, Cytokines, lcsh:Q, Inflammation Mediators, Immunology/Genetics of the Immune System, Viral load, Research Article |
| الوصف: | The genetic make-up of the host has a major influence on its response to combat pathogens. For influenza A virus, several single gene mutations have been described which contribute to survival, the immune response and clearance of the pathogen by the host organism. Here, we have studied the influence of the genetic background to influenza A H1N1 (PR8) and H7N7 (SC35M) viruses. The seven inbred laboratory strains of mice analyzed exhibited different weight loss kinetics and survival rates after infection with PR8. Two strains in particular, DBA/2J and A/J, showed very high susceptibility to viral infections compared to all other strains. The LD(50) to the influenza virus PR8 in DBA/2J mice was more than 1000-fold lower than in C57BL/6J mice. High susceptibility in DBA/2J mice was also observed after infection with influenza strain SC35M. In addition, infected DBA/2J mice showed a higher viral load in their lungs, elevated expression of cytokines and chemokines, and a more severe and extended lung pathology compared to infected C57BL/6J mice. These findings indicate a major contribution of the genetic background of the host to influenza A virus infections. The overall response in highly susceptible DBA/2J mice resembled the pathology described for infections with the highly virulent influenza H1N1-1918 and newly emerged H5N1 viruses. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08372c626d8e22a7e4cb26b06b78b04Test https://refubium.fu-berlin.de/handle/fub188/14585Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b08372c626d8e22a7e4cb26b06b78b04 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |