Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study
| العنوان: | Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study |
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| المؤلفون: | García-Sancho, Alejandro Martín, Bellei, Monica, López-Parra, Miriam, Gritti, Giuseppe, Cortés, María, Novelli, Silvana, Panizo, Carlos, Petrucci, Luigi, Gutiérrez, Antonio, Dlouhy, Ivan, Bastos, Mariana, Sancho, Juan M., Ramírez, María J., Moraleda, José M., Carrillo, Estrella, Jiménez-Ubieto, Ana I., Jarque, Isidro, Orsucci, Lorella, García-Torres, Estefanía, Montalbán, Carlos, Dodero, Anna, Arranz, Reyes, De las Heras, Natalia, Pascual, María J., López-Jiménez, Javier, Spina, Michelle, Re, Alessandro, de Villambrosia, Sonia González, Bobillo, Sabela, Federico, Massimo, Caballero, Dolores, Universitat Autònoma de Barcelona |
| المساهمون: | Institut Català de la Salut, [García-Sancho AM, López-Parra M] Department of Hematology, Hospital Universitario de Salamanca, IBSAL, CIBERONC, Salamanca, Spain. [Bellei M] Fondazione Italiana Linfomi (FIL) Onlus, Modena, Italy. [Gritti G] Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy. [Cortés M] Department of Statistics, Hospital Universitario de Salamanca / IBSAL, Salamanca, Spain. [Novelli S] Hematology Department, Hospital de la Santa Creu i Sant Pau, José Carreras Leukemia Research Institute and IIB Sant Pau, Barcelona, Spain. [Bobillo S] Servei d’Hematologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Ferrata Storti Foundation (Haematologica), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | neoplasias::neoplasias por tipo histológico::linfoma::linfoma no Hodgkin::linfoma de células T::linfoma de células T periféricas [ENFERMEDADES], Cèl·lules mare hematopoètiques - Trasplantació, Hematopoietic Stem Cell Transplantation, Surgical Procedures, Operative::Transplantation::Transplantation, Autologous [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Lymphoma, T-Cell, Peripheral, Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Hematology, Other subheadings::Other subheadings::/drug therapy [Other subheadings], Transplantation, Autologous, Disease-Free Survival, Hodgkin, Malaltia de - Tractament, Antineoplastic Combined Chemotherapy Protocols, Humans, Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, T-Cell::Lymphoma, T-Cell, Peripheral [DISEASES], Prospective Studies, terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre hematopoyéticas [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], intervenciones quirúrgicas::trasplante::trasplante autólogo [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Retrospective Studies |
| الوصف: | Autologous stem-cell transplantation; Chemotherapy; T-cell lymphoma Trasplante autólogo de células madre; Quimioterapia; Linfoma de células T Trasplantament autòleg de cèl·lules mare; Quimioteràpia; Limfoma de cèl·lules T Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments. Upfront consolidation with autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigated in randomized trials. We designed a multicenter, international, retrospective study with the main objective of comparing progression-free survival and overall survival of patients with PTCL who underwent ASCT in complete remission (CR) after first-line chemotherapy with a control group who did not undergo ASCT. From the initial population of 286 registered patients, 174 patients with PTCL other than anaplastic large cell lymphoma, ALK-positive, deemed fit for ASCT at the time of diagnosis, and who were in CR or uncertain CR after induction therapy (CR1) were included in our analysis. one hundred and three patients underwent ASCT, whereas 71 did not, in most cases (n=53) because the physician decided against it. With a median follow-up of 65.5 months, progression-free survival was significantly better in the transplanted patients than in the non-transplanted group: 63% versus 48% at 5 years (P=0.042). Overall survival was significantly longer for ASCT patients in the subgroup with advanced stage at diagnosis (5-year overall survival: 70% vs. 50%, P=0.028). In the multivariate analysis, first-line ASCT was associated with significantly prolonged progression-free survival (HR=0.57, 95% CI: 0.35-0.93) and overall survival (HR=0.57, 95% CI: 0.33-0.99). In conclusion, our study supports the use of ASCT as a consolidation strategy for patients with PTCL in CR1. These results should be confirmed in a prospective randomized study. |
| وصف الملف: | application/pdf |
| تدمد: | 1592-8721 0390-6078 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b434425e486ab470d16696d98243fe05Test https://doi.org/10.3324/haematol.2021.279426Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b434425e486ab470d16696d98243fe05 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15928721 03906078 |
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