Vaccine strategies against schistosomiasis
| العنوان: | Vaccine strategies against schistosomiasis |
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| المؤلفون: | André Capron, J. Pierce, Jean-Paul Dessaint, Monique Capron |
| المصدر: | Memórias do Instituto Oswaldo Cruz, Volume: 87 Supplement 5, Pages: 1-9, Published: 1992 Memórias do Instituto Oswaldo Cruz, Volume: 87 Supplement 4, Pages: 19-27, Published: 1992 Memórias do Instituto Oswaldo Cruz., Vol 87, Pp 1-9 (1992) Memórias do Instituto Oswaldo Cruz., Vol 87, Pp 19-27 (1992) |
| بيانات النشر: | FapUNIFESP (SciELO), 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | Cellular immunity, lcsh:QR1-502, Immunoglobulin E, lcsh:Microbiology, Praziquantel, Mice, T-Lymphocyte Subsets, vaccine, Immunology and Allergy, Schistosomiasis, Cloning, Molecular, vaccine strategies, Schistosoma haematobium, Immunity, Cellular, Vaccines, education.field_of_study, biology, Hematology, Helminth Proteins, protection, Immunoglobulin Isotypes, Vaccination, Schistosoma, Immunotherapy, Disease Susceptibility, IgE, Antibody, IgA, Microbiology (medical), lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Immunology, Population, Helminthiasis, Antibodies, Helminth, Models, Biological, Host-Parasite Interactions, Immune system, Species Specificity, Antigen, schistosomiasis, Blocking antibody, medicine, Animals, Humans, education, Antibody-Dependent Cell Cytotoxicity, medicine.disease, biology.organism_classification, Virology, Schistosomiasis mansoni, Immunoglobulin A, Rats, Disease Models, Animal, immunity regulation, Gene Expression Regulation, Immunization, Antigens, Helminth, biology.protein, Cattle |
| الوصف: | Schistosomiasis, the second major parasitic disease in the world after malaria affects at least 200 million people, 500 million being exposed to the risk of infection. It is widely agreed that a vaccine strategy wich could lead to the induction of effector mechanisms reducing the level of reinfection and ideally parasite fecundity would deeply affect the incidence of pathological manifestations as well as the parasite transmission potentialities. Extensive studies performed in the rat model have allowed the identification of novel effector mechanisms involving IgE antibodies and various inflammatory cell populations (eosinophils, macrophages and platelets) whereas regulation of immune response by blocking antibodies has been evidencial. Recent epidemiological studies have now entirely confirmed in human populations the the role of IgE antibodies in the acquisition of resistance and the association of IgG4 blocking antibodies with increased susceptibility. On the basis of these concepts, several schistosome glutathion S-transferase (Sm 28 GST) appears as a pronising vaccine candidate. Immunization experiments have shown that two complementary goals can be achieved: (a) a partial but significant reduction of the worm population (up to 60//in rats); (b) a significant reduction of parasite fecundity (up in the mice and 85//in cattle) and egg viability (up to 80//). At least two distinct immunological mechanisms account for these two effects. IgE antibodies appear as a major humoral component of acquired resistance whereas IgA antibodies appear as a major humoral factor affecting parasite fecundity. These studies seem to represent a parasite diseases through the identification of potentially protective antigens and of the components of the immune response which vaccination should aim at inducing. |
| وصف الملف: | text/html |
| تدمد: | 0074-0276 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339100351cae0889e9583111647a7ed4Test https://doi.org/10.1590/s0074-02761992000900001Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....339100351cae0889e9583111647a7ed4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00740276 |
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