GABA-induced inactivation of Cebus apella V2 neurons: effects on orientation tuning and direction selectivity
| العنوان: | GABA-induced inactivation of Cebus apella V2 neurons: effects on orientation tuning and direction selectivity |
|---|---|
| المؤلفون: | Ricardo Gattass, Ana Karla Jansen-Amorim, Mario Fiorani |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 46, Iss 7, Pp 589-600 (2013) Brazilian Journal of Medical and Biological Research v.46 n.7 2013 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Volume: 46, Issue: 7, Pages: 589-600, Published: 22 JUL 2013 |
| بيانات النشر: | FapUNIFESP (SciELO), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Time Factors, GABA Agents, Physiology, Immunology, Biophysics, Neural Inhibition, Stimulus (physiology), Biochemistry, gamma-Aminobutyric acid, Electrocardiography, Orientation, Extracellular recordings, medicine, Extracellular, Animals, Cebus, Visual cortex, General Pharmacology, Toxicology and Pharmaceutics, lcsh:QH301-705.5, gamma-Aminobutyric Acid, Neurons, New World monkeys, lcsh:R5-920, Single units, Chemistry, General Neuroscience, Biomedical Sciences, Lidocaine, Cell Biology, General Medicine, Anatomy, medicine.anatomical_structure, lcsh:Biology (General), nervous system, Receptive field, lcsh:Medicine (General), Selectivity, Microelectrodes, Photic Stimulation, medicine.drug |
| الوصف: | We investigated the GABA-induced inactivation of V2 neurons and terminals on the receptive field properties of this area in an anesthetized and paralyzed Cebus apella monkey. Extracellular single-unit activity was recorded using tungsten microelectrodes in a monkey before and after pressure-injection of a 0.25 or 0.5 M GABA solution. The visual stimulus consisted of a bar moving in 8 possible directions. In total, 24 V2 neurons were studied before and after blocker injections in 4 experimental sessions following GABA injection into area V2. A group of 10 neurons were studied over a short period. An additional 6 neurons were investigated over a long period after the GABA injection. A third group of 8 neurons were studied over a very long period. Overall, these 24 neurons displayed an early (1-20 min) significant general decrease in excitability with concomitant changes in orientation or direction selectivity. GABA inactivation in area V2 produced robust inhibition in 80% and a significant change in directional selectivity in 60% of the neurons examined. These GABA projections are capable of modulating not only levels of spontaneous and driven activity of V2 neurons but also receptive field properties such as direction selectivity. |
| وصف الملف: | text/html |
| تدمد: | 0100-879X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d3aac4a04ba349f012cb44a2407f41Test https://doi.org/10.1590/1414-431x20132859Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e1d3aac4a04ba349f012cb44a2407f41 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0100879X |
|---|