The experimental granuloma: a hypothesis to explain the persistence of the lesion
| العنوان: | The experimental granuloma: a hypothesis to explain the persistence of the lesion |
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| المؤلفون: | M Mariano |
| المصدر: | Revista do Instituto de Medicina Tropical de São Paulo, Volume: 37, Issue: 2, Pages: 161-176, Published: APR 1995 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 2 (1995); 161-176 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 2 (1995); 161-176 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 2 (1995); 161-176 Revista do Instituto de Medicina Tropical de São Paulo Instituto de Medicina Tropical (IMT) instacron:IMT |
| بيانات النشر: | FapUNIFESP (SciELO), 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, MDF, Tuberculosis, Granulona, Macrophage, Inflammation, Schistosomiasis, MRP-14, Biology, Lesion, Mice, medicine, Animals, Calgranulin B, Humans, Calgranulin A, Granulomatous inflammation, Macrophage Migration-Inhibitory Factors, Granuloma, Epithelioid cell, Macrophages, Calcium-Binding Proteins, Epithelioid Cells, General Medicine, medicine.disease, Antigens, Differentiation, Leprosy, Tuberculoid, Infectious Diseases, Cell Migration Inhibition, Immunology, Macrophage migration inhibitory factor, medicine.symptom |
| الوصف: | A inflamação glanulomatosa é o substrato morfológico de uma variedade de doenças infecciosas importantes tais como tuberculose, lepra, esquistossomose e outras. Embora muitos aspectos deste tipo especial de inflamação sejam conhecidos, questões fundamentais referentes à formação do granulona, persistência, destino e significado da relação hospedeiro-parasita permanecem para serem elucidados. Nesta revisão é apresentada a literatura básica e mais relevante relacionada à investigação experimental sobre a fisiopatologia do granuloma. Baseados em investigações recentes realizadas, em nosso laboratório mostrando que o fator de desativação do macrófago (MDF) secretado pelas células epitelióides e caracterizado pela proteína MRP-14, uma proteína ligante de cálcio, foi levantada hipótese para explicar a persistência da inflamação granulomatosa. Granulomatous inflammation is the morphological substrate of a variety of important infectious diseases such as tuberculosis, leprosy, schistosomiasis and others. Nevertheless, although many aspects of this special type of inflammation are known, fundamental questions concerning granuloma formation, persistence, fate and significance for host-parasite relationships still remain to be elucidated. In this brief review, the basic and more relevant literature related to experimental investigations on granuloma physiopathology is presented. Based on recent investigations performed in our laboratory showing that MDF (Macrophage Deactivating Fator) secreted by epithelioid cells and characterized as the calcium-binding protein protein MRP-14 deactivates activated macrophages, a hypothesis to explain the persistence of granulomatous inflammation is put forward |
| وصف الملف: | text/html; application/pdf |
| تدمد: | 0036-4665 1678-9946 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9838f84764892dc459ddbf49e8b9178Test https://doi.org/10.1590/s0036-46651995000200012Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c9838f84764892dc459ddbf49e8b9178 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00364665 16789946 |
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