Effectiveness and safety of first-generation protease inhibitors in real-world patients with hepatitis C virus genotype 1 infection in Brazil: a multicenter study
| العنوان: | Effectiveness and safety of first-generation protease inhibitors in real-world patients with hepatitis C virus genotype 1 infection in Brazil: a multicenter study |
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| المؤلفون: | Callefi, Luciana Azevedo, Villela-Nogueira, Cristiane Alves, Tenore, Simone de Barros, Carnauba-Junior, Dimas, Moraes Coelho, Henrique Sergio, Pinto, Paulo de Tarso A., Nabuco, Leticia Cancella, Pessoa, Mario Guimaraes, Cardoso Gomes Ferraz, Maria Lucia [UNIFESP], Abrao Ferreira, Paulo Roberto [UNIFESP], Candolo Martinelli, Ana de Lourdes, Florencio Chacha, Silvana Gama, Paiva Ferreira, Adalgisa de Souza, de Macedo Bisio, Alessandra Porto, Brandao-Mello, Carlos Eduardo, Alvares-Da-Silva, Mario Reis, Reuter, Tania, Alexandra, Claudia, Ivantes, Pontes, Perez, Renata de Mello, Jacintho Mendes-Correa, Maria Cassia |
| المصدر: | Clinics, Volume: 72, Issue: 6, Pages: 378-385, Published: JUN 2017 Clinics Clinics, Vol 72, Iss 6, Pp 378-385 Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Clinics; v. 72 n. 6 (2017); 378-385 Clinics; Vol. 72 Núm. 6 (2017); 378-385 Clinics; Vol. 72 No. 6 (2017); 378-385 Universidade de São Paulo (USP) instacron:USP Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| بيانات النشر: | Faculdade de Medicina / USP, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Cirrhosis, medicine.medical_treatment, Hepacivirus, Telaprevir, Antivirais, Polyethylene Glycols, chemistry.chemical_compound, 0302 clinical medicine, Genotype, Meia-idade, Chronic, Hepatite C crônica, lcsh:R5-920, General Medicine, Hepatitis C, Middle Aged, Clinical Science, Recombinant Proteins, Treatment Outcome, RNA, Viral, Female, Safety, 0305 other medical science, lcsh:Medicine (General), Oligopeptides, Brazil, medicine.drug, medicine.medical_specialty, Proline, 030231 tropical medicine, Therapeutics, Interferon alpha-2, Proteínas recombinantes, Antiviral Agents, 03 medical and health sciences, Boceprevir, Internal medicine, medicine, Humans, Protease Inhibitors, Adverse effect, Aged, 030505 public health, Protease, business.industry, Ribavirin, Brasil, Interferon-alpha, Hepatitis C, Chronic, Protease inhibitors, medicine.disease, Cross-Sectional Studies, chemistry, Immunology, business, RNA viral |
| الوصف: | OBJECTIVE: To evaluate the effectiveness and safety of first-generation protease inhibitors for the treatment of genotype 1 hepatitis C virus-infected patients at Brazilian reference centers. METHODS: This multicenter cross-sectional study included hepatitis C virus genotype 1 monoinfected patients treated with Peg-interferon, ribavirin, and either boceprevir (n=158) or telaprevir (n=557) between July 2013 and April 2014 at 15 reference centers in Brazil. Demographic, clinical, virological, and adverse events data were collected during treatment and follow-up. RESULTS: Of the 715 patients, 59% had cirrhosis and 67.1% were treatment-experienced. Based on intention-to-treat analysis, the overall sustained viral response was 56.6%, with similar effectiveness in both groups (51.9% for boceprevir and 58% for telaprevir, p=0.190). Serious adverse events occurred in 44.2% of patients, and six deaths (0.8%) were recorded. Cirrhotic patients had lower sustained viral response rates than non-cirrhotic patients (46.9% vs. 70.6%, p < 0.001) and a higher incidence of serious adverse events (50.7% vs. 34.8%, p < 0.001). Multivariate analysis revealed that sustained viral response was associated with the absence of cirrhosis, viral recurrence after previous treatment, pretreatment platelet count greater than 100,000/mm(3), and achievement of a rapid viral response. Female gender, age > 465 years, diagnosis of cirrhosis, and abnormal hemoglobin levels/platelet counts prior to treatment were associated with serious adverse events. CONCLUSION: Although serious adverse events rates were higher in this infected population, sustained viral response rates were similar to those reported for other patient cohorts. Univ Sao Paulo, Fac Med, Dept Molestias Infecciosas & Parasitarias, Sao Paulo, SP, Brazil Univ Fed Rio de Janeiro, Rio De Janeiro, RJ, Brazil Ctr Referencia & Treinamento DST Aids, Sao Paulo, SP, Brazil CDH, Rio De Janeiro, RJ, Brazil Hosp Fed Servidores Estado Rio de Janeiro HFSE, Setor Gastrohepatol, Rio De Janeiro, RJ, Brazil Univ Sao Paulo, Fac Med, Dept Gastroenterol & Hepatol, Sao Paulo, SP, Brazil Univ Fed Sao Paulo UNIFESP, Disciplina Gastroenterol, EPM, Sao Paulo, SP, Brazil Univ Fed Sao Paulo UNIFESP, EPM, Disciplina Infectol, Sao Paulo, SP, Brazil Univ Sao Paulo, FMRP, Dept Clin Med, Div Gastroenterol, Sao Paulo, SP, Brazil| Univ Fed do Maranhao UFMA, HUPD, Ctr Pesquisa Clin, Sao Luis, MA, Brazil Univ Fed Estado Rio de Janeiro UNIRIO, Disciplina Clin Med & Gastroenterol, Rio De Janeiro, RJ, Brazil Univ Fed Rio do Grande Sul UFRGS, Dept Med Interna, Porto Alegre, RS, Brazil Univ Fed Espirito Santo, Ambulatorio HIV AIDS Hepatites Virais, Vitoria, ES, Brazil SMS, Ctr Orientacao & Aconselhamento, Foz Do Iguacu, PR, Brazil Univ Estado Rio de Janeiro UERJ, Serv Gastroenterol, Rio De Janeiro, RJ, Brazil IMT, Lab Virol LIM 52, Sao Paulo, SP, Brazil Univ Fed Sao Paulo UNIFESP, Disciplina Gastroenterol, EPM, Sao Paulo, SP, Brazil Univ Fed Sao Paulo UNIFESP, EPM, Disciplina Infectol, Sao Paulo, SP, Brazil Web of Science |
| وصف الملف: | text/html; application/pdf |
| اللغة: | English |
| تدمد: | 1980-5322 1807-5932 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633728cef1aa21a6cbfc47fdf1eba9d3Test http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322017000600378&lng=en&tlng=enTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....633728cef1aa21a6cbfc47fdf1eba9d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19805322 18075932 |
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