دورية أكاديمية
Recent advances in the understanding of autophagosome biogenesis [version 1; peer review: 2 approved]
| العنوان: | Recent advances in the understanding of autophagosome biogenesis [version 1; peer review: 2 approved] |
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| المؤلفون: | Martin Graef |
| المصدر: | F1000Research, Vol 9 (2020) |
| بيانات النشر: | F1000 Research Ltd, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Autophagy is a conserved catabolic process critical for cell homeostasis with broad implications for aging and age-associated diseases. A defining feature of autophagy is the de novo formation of a specialized transient organelle, the double-membrane autophagosome. Autophagosomes originate from small vesicular precursors after rapid membrane expansion resulting in the engulfment of a broad spectrum of cytoplasmic cargoes within a few minutes for vacuolar or lysosomal degradation. Recent advances have provided exciting new insights into the molecular mechanisms underlying the assembly of autophagic membranes during autophagosome biogenesis. Specifically, the phospholipid biosynthesis activity of the endoplasmic reticulum and a dedicated membrane-tethering complex between nascent autophagosomes and the endoplasmic reticulum have emerged as key factors in autophagosome formation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2046-1402 |
| العلاقة: | https://f1000research.com/articles/9-212/v1Test; https://doaj.org/toc/2046-1402Test |
| DOI: | 10.12688/f1000research.22111.1 |
| الوصول الحر: | https://doaj.org/article/621eaec88fc84b68bc0eeae30a361305Test |
| رقم الانضمام: | edsdoj.621eaec88fc84b68bc0eeae30a361305 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20461402 |
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| DOI: | 10.12688/f1000research.22111.1 |