المؤلفون: Mullins, Niamh, Kang, JooEun, Campos, Adrian I., Coleman, Jonathan R.I., Edwards, Alexis C., Galfalvy, Hanga, Levey, Daniel F., Lori, Adriana, Shabalin, Andrey, Starnawska, Anna, Su, Mei-Hsin, Watson, Hunna J., Adams, Mark, Awasthi, Swapnil, Gandal, Michael, Hafferty, Jonathan D., Hishimoto, Akitoyo, Kim, Minsoo, Okazaki, Satoshi, Otsuka, Ikuo, Ripke, Stephan, Ware, Erin B., Bergen, Andrew W., Berrettini, Wade H., Bohus, Martin, Brandt, Harry, Chang, Xiao, Chen, Wei J., Chen, Hsi-Chung, Crawford, Steven, Crow, Scott, DiBlasi, Emily, Duriez, Philibert, Fernández-Aranda, Fernando, Fichter, Manfred M., Gallinger, Steven, Glatt, Stephen J., Gorwood, Philip, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine A., Hwu, Hai-Gwo, Jain, Sonia, Jamain, Stéphane, Jiménez-Murcia, Susana, Johnson, Craig, Kaplan, Allan S., Kaye, Walter H., Keel, Pamela K., Kennedy, James L., Klump, Kelly L., Li, Dong, Liao, Shih-Cheng, Lieb, Klaus, Lilenfeld, Lisa, Liu, Chih-Min, Magistretti, Pierre J., Marshall, Christian R., Mitchell, James E., Monson, Eric T., Myers, Richard M., Pinto, Dalila, Powers, Abigail, Ramoz, Nicolas, Roepke, Stefan, Rozanov, Vsevolod, Scherer, Stephen W., Schmahl, Christian, Sokolowski, Marcus, Strober, Michael, Thornton, Laura M., Treasure, Janet, Tsuang, Ming T., Witt, Stephanie H., Woodside, D. Blake, Yilmaz, Zeynep, Zillich, Lea, Adolfsson, Rolf, Agartz, Ingrid, Air, Tracy M., Alda, Martin, Alfredsson, Lars, Andreassen, Ole A., Anjorin, Adebayo, Appadurai, Vivek, Soler Artigas, María, der Auwera, Sandra Van, Azevedo, M. Helena, Bass, Nicholas, Bau, Claiton H.D., Baune, Bernhard T., Bellivier, Frank, Berger, Klaus, Biernacka, Joanna M., Bigdeli, Tim B., Binder, Elisabeth B., Boehnke, Michael, Boks, Marco P., Bosch, Rosa, Braff, David L., Bryant, Richard, Budde, Monika, Byrne, Enda M., Cahn, Wiepke, Casas, Miguel, Castelao, Enrique, Cervilla, Jorge A., Chaumette, Boris, Cichon, Sven, Corvin, Aiden, Craddock, Nicholas, Craig, David, Degenhardt, Franziska, Djurovic, Srdjan, Edenberg, Howard J., Fanous, Ayman H., Foo, Jerome C., Forstner, Andreas J., Frye, Mark, Fullerton, Janice M., Gatt, Justine M., Gejman, Pablo V., Giegling, Ina, Grabe, Hans J., Green, Melissa J., Grevet, Eugenio H., Grigoroiu-Serbanescu, Maria, Gutierrez, Blanca, Guzman-Parra, Jose, Hamilton, Steven P., Hamshere, Marian L., Hartmann, Annette, Hauser, Joanna, Heilmann-Heimbach, Stefanie, Hoffmann, Per, Ising, Marcus, Jones, Ian, Jones, Lisa A., Jonsson, Lina, Kahn, René S., Kelsoe, John R., Kendler, Kenneth S., Kloiber, Stefan, Koenen, Karestan C., Kogevinas, Manolis, Konte, Bettina, Krebs, Marie-Odile, Landén, Mikael, Lawrence, Jacob, Leboyer, Marion, Lee, Phil H., Levinson, Douglas F., Liao, Calwing, Lissowska, Jolanta, Lucae, Susanne, Mayoral, Fermin, McElroy, Susan L., McGrath, Patrick, McGuffin, Peter, McQuillin, Andrew, Medland, Sarah E., Mehta, Divya, Melle, Ingrid, Milaneschi, Yuri, Mitchell, Philip B., Molina, Esther, Morken, Gunnar, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Nievergelt, Caroline M., Nimgaonkar, Vishwajit, Nöthen, Markus M., O’Donovan, Michael C., Ophoff, Roel A., Owen, Michael J., Pato, Carlos, Pato, Michele T., Penninx, Brenda W.J.H., Pimm, Jonathan, Pistis, Giorgio, Potash, James B., Power, Robert A., Preisig, Martin, Quested, Digby, Ramos-Quiroga, Josep Antoni, Reif, Andreas, Ribasés, Marta, Richarte, Vanesa, Rietschel, Marcella, Rivera, Margarita, Roberts, Andrea, Roberts, Gloria, Rouleau, Guy A., Rovaris, Diego L., Rujescu, Dan, Sánchez-Mora, Cristina, Sanders, Alan R., Schofield, Peter R., Schulze, Thomas G., Scott, Laura J., Serretti, Alessandro, Shi, Jianxin, Shyn, Stanley I., Sirignano, Lea, Sklar, Pamela, Smeland, Olav B., Smoller, Jordan W., Sonuga-Barke, Edmund J.S., Spalletta, Gianfranco, Strauss, John S., Świątkowska, Beata, Trzaskowski, Maciej, Turecki, Gustavo, Vilar-Ribó, Laura, Vincent, John B., Völzke, Henry, Walters, James T.R., Shannon Weickert, Cynthia, Weickert, Thomas W., Weissman, Myrna M., Williams, Leanne M., Wray, Naomi R., Zai, Clement C., Ashley-Koch, Allison E., Beckham, Jean C., Hauser, Elizabeth R., Hauser, Michael A., Kimbrel, Nathan A., Lindquist, Jennifer H., McMahon, Benjamin, Oslin, David W., Qin, Xuejun, Mattheisen, Manuel, Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Colodro-Conde, Lucía, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Davies, Gail, Derks, Eske M., Direk, Nese, Dolan, Conor V., Dunn, Erin C., Eley, Thalia C., Escott-Price, Valentina, Hassan Kiadeh, Farnush Farhadi, Finucane, Hilary K., Frank, Josef, Gaspar, Héléna A., Gill, Michael, Goes, Fernando S., Gordon, Scott D., Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Wu, Yang, Xi, Simon, Yang, Jian, Zhang, Futao, Arolt, Volker, Boomsma, Dorret I., Dannlowski, Udo, de Geus, E.J.C., Depaulo, J. Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tõnu, Grove, Jakob, Hall, Lynsey S., Hansen, Christine Søholm, Hansen, Thomas F., Herms, Stefan, Hickie, Ian B., Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Hougaard, David M., Howard, David M., Jansen, Rick, Jorgenson, Eric, Knowles, James A., Kohane, Isaac S., Kraft, Julia, Kretzschmar, Warren W., Kutalik, Zoltán, Li, Yihan, Lind, Penelope A., MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, Middeldorp, Christel M., Mihailov, Evelin, Milani, Lili, Mondimore, Francis M., Montgomery, Grant W., Mostafavi, Sara, Nauck, Matthias, Ng, Bernard, Nivard, Michel G., Nyholt, Dale R., O’Reilly, Paul F., Oskarsson, Hogni, Hayward, Caroline, Heath, Andrew C., Lewis, Glyn, Li, Qingqin S., Madden, Pamela A.F., Magnusson, Patrik K., Martin, Nicholas G., McIntosh, Andrew M., Metspalu, Andres, Mors, Ole, Nordentoft, Merete, Paciga, Sara A., Pedersen, Nancy L., Painter, Jodie N., Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Peterson, Roseann E., Peyrot, Wouter J., Posthuma, Danielle, Quiroz, Jorge A., Qvist, Per, Rice, John P., Riley, Brien P., Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C., Shen, Ling, Sigurdsson, Engilbert, Sinnamon, Grant C.B., Smit, Johannes H., Smith, Daniel J., Stefansson, Hreinn, Steinberg, Stacy, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, André G., Umbricht, Daniel, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Webb, Bradley T., Perlis, Roy H., Porteous, David J., Schaefer, Catherine, Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Werge, Thomas, Lewis, Cathryn M., Breen, Gerome, Børglum, Anders D., Sullivan, Patrick F., O’Connell, Kevin S., Coombes, Brandon, Qiao, Zhen, Als, Thomas D., Børte, Sigrid, Charney, Alexander W., Drange, Ole Kristian, Gandal, Michael J., Hagenaars, Saskia P., Ikeda, Masashi, Kamitaki, Nolan, Krebs, Kristi, Panagiotaropoulou, Georgia, Schilder, Brian M., Sloofman, Laura G., Winsvold, Bendik S., Won, Hong-Hee, Abramova, Liliya, Adorjan, Kristina, Al Eissa, Mariam, Albani, Diego, Alliey-Rodriguez, Ney, Antilla, Verneri, Antoniou, Anastasia, Baek, Ji Hyun, Bauer, Michael, Beins, Eva C., Bergen, Sarah E., Birner, Armin, Bøen, Erlend, Brum, Murielle, Brumpton, Ben M., Brunkhorst-Kanaan, Nathalie, Byerley, William, Cairns, Murray, Casas, Miquel, Cervantes, Pablo, Cruceanu, Cristiana, Cuellar-Barboza, Alfredo, Cunningham, Julie, Curtis, David, Czerski, Piotr M., Dale, Anders M., Dalkner, Nina, David, Friederike S., Dobbyn, Amanda L., Douzenis, Athanassios, Elvsåshagen, Torbjørn, Ferrier, I. Nicol, Fiorentino, Alessia, Foroud, Tatiana M., Forty, Liz, Frei, Oleksandr, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Garnham, Julie, Gelernter, Joel, Gizer, Ian R., Gordon-Smith, Katherine, Greenwood, Tiffany A., Guzman-Parra, José, Ha, Kyooseob, Haraldsson, Magnus, Hautzinger, Martin, Heilbronner, Urs, Hellgren, Dennis, Holmans, Peter A., Huckins, Laura, Johnson, Jessica S., Kalman, Janos L., Kamatani, Yoichiro, Kittel-Schneider, Sarah, Koromina, Maria, Kranz, Thorsten M., Kranzler, Henry R., Kubo, Michiaki, Kupka, Ralph, Kushner, Steven A., Lavebratt, Catharina, Leber, Markus, Lee, Heon-Jeong, Levy, Shawn E., Lewis, Catrin, Lundberg, Martin, Magnusson, Sigurdur H., Maihofer, Adam, Malaspina, Dolores, Maratou, Eirini, Martinsson, Lina, McGregor, Nathaniel W., McKay, James D., Medeiros, Helena, Millischer, Vincent, Moran, Jennifer L., Morris, Derek W., Mühleisen, Thomas W., O’Brien, Niamh, O’Donovan, Claire, Olde Loohuis, Loes M., Oruc, Lilijana, Papiol, Sergi, Pardiñas, Antonio F., Perry, Amy, Pfennig, Andrea, Porichi, Evgenia, Raj, Towfique, Rapaport, Mark H., DePaulo, J. Raymond, Regeer, Eline J., Rivas, Fabio, Roth, Julian, Roussos, Panos, Ruderfer, Douglas M., Senner, Fanny, Sharp, Sally, Shilling, Paul D., Slaney, Claire, Sobell, Janet L., Artigas, Maria Soler, Spijker, Anne T., Stein, Dan J., Terao, Chikashi, Toma, Claudio, Tooney, Paul, Tsermpini, Evangelia-Eirini, Vawter, Marquis P., Vedder, Helmut, Xu, Wei, Kay Yang, Jessica Mei, Young, Allan H., Young, Hannah, Zandi, Peter P., Zhou, Hang, Psychiatry, HUNT All-In, Babadjanova, Gulja, Backlund, Lena, Bengesser, Susanne, Blackwood, Douglas H.R., Carr, Vaughan J., Catts, Stanley, Dikeos, Dimitris, Etain, Bruno, Ferentinos, Panagiotis, Gawlik, Micha, Gershon, Elliot S., Henskens, Frans, Hillert, Jan, Hong, Kyung Sue, Hultman, Christina M., Hveem, Kristian, Iwata, Nakao, Jablensky, Assen V., Kirov, George, Lochner, Christine, Loughland, Carmel, Mathews, Carol A., McMahon, Francis J., Michie, Patricia, Mowry, Bryan, Neale, Benjamin M., Oedegaard, Ketil J., Olsson, Tomas, Pantelis, Chris, Patrinos, George P., Reininghaus, Eva Z., Saito, Takeo, Schall, Ulrich, Schalling, Martin, Scott, Rodney J., Weickert, Cynthia Shannon, Stordal, Eystein, Vaaler, Arne E., Vieta, Eduard, Waldman, Irwin D., Zwart, John-Anker, Nurnberger, John I., Stahl, Eli A., Di Florio, Arianna, Adan, Roger A.H., Ando, Tetsuya, Aschauer, Harald, Baker, Jessica H., Bencko, Vladimir, Birgegård, Andreas, Boden, Joseph M., Boehm, Ilka, Boni, Claudette, Perica, Vesna Boraska, Buehren, Katharina, Bulik, Cynthia M., Burghardt, Roland, Carlberg, Laura, Cassina, Matteo, Clementi, Maurizio, Cone, Roger D., Courtet, Philippe, Crowley, James J., Danner, Unna N., Davis, Oliver S.P., de Zwaan, Martina, Dedoussis, George, Degortes, Daniela, DeSocio, Janiece E., Dick, Danielle M., Dina, Christian, Dmitrzak-Weglarz, Monika, Martinez, Elisa Docampo, Duncan, Laramie E., Egberts, Karin, Mattingsdal, Morten, McDevitt, Sara, Meulenbelt, Ingrid, Micali, Nadia, Mitchell, James, Mitchell, Karen, Monteleone, Palmiero, Monteleone, Alessio Maria, Munn-Chernoff, Melissa A., Nacmias, Benedetta, Navratilova, Marie, Ntalla, Ioanna, Olsen, Catherine M., O’Toole, Julie K., Padyukov, Leonid, Palotie, Aarno, Pantel, Jacques, Papezova, Hana, Parker, Richard, Pearson, John F., Ehrlich, Stefan, Escaramís, Geòrgia, Espeseth, Thomas, Estivill, Xavier, Farmer, Anne, Favaro, Angela, Fischer, Krista, Floyd, James A.B., Föcker, Manuel, Foretova, Lenka, Forzan, Monica, Franklin, Christopher S., Gambaro, Giovanni, Giuranna, Johanna, Giusti-Rodríquez, Paola, Gonidakis, Fragiskos, Gordon, Scott, Mayora, Monica Gratacos, Guillaume, Sébastien, Hanscombe, Ken B., Hatzikotoulas, Konstantinos, Hebebrand, Johannes, Helder, Sietske G., Henders, Anjali K., Herpertz-Dahlmann, Beate, Herzog, Wolfgang, Hinney, Anke, Horwood, L. John, Hübel, Christopher, Petersen, Liselotte V., Purves, Kirstin L., Raevuori, Anu, Reichborn-Kjennerud, Ted, Ricca, Valdo, Ripatti, Samuli, Ritschel, Franziska, Roberts, Marion, Rybakowski, Filip, Santonastaso, Paolo, Scherag, André, Schmidt, Ulrike, Schork, Nicholas J., Schosser, Alexandra, Seitz, Jochen, Slachtova, Lenka, Slagboom, P. Eline, Slof-Op ‘t Landt, Margarita C.T., Slopien, Agnieszka, Soranzo, Nicole, Sorbi, Sandro, Southam, Lorraine, Steen, Vidar W., Huckins, Laura M., Hudson, James I., Imgart, Hartmut, Inoko, Hidetoshi, Janout, Vladimir, Jordan, Jennifer, Julià, Antonio, Kalsi, Gursharan, Kaminská, Deborah, Kaprio, Jaakko, Karhunen, Leila, Karwautz, Andreas, Kas, Martien J.H., Kennedy, Martin A., Keski-Rahkonen, Anna, Kiezebrink, Kirsty, Kim, Youl-Ri, Kirk, Katherine M., Klareskog, Lars, Knudsen, Gun Peggy S., Larsen, Janne T., Le Hellard, Stephanie, Leppä, Virpi M., Lichtenstein, Paul, Lin, Bochao Danae, Lundervold, Astri, Luykx, Jurjen, Maj, Mario, Mannik, Katrin, Marsal, Sara, Stuber, Garret D., Szatkiewicz, Jin P., Tachmazidou, Ioanna, Tenconi, Elena, Tortorella, Alfonso, Tozzi, Federica, Tsitsika, Artemis, Tyszkiewicz-Nwafor, Marta, Tziouvas, Konstantinos, van Elburg, Annemarie A., van Furth, Eric F., Wade, Tracey D., Wagner, Gudrun, Walton, Esther, Whiteman, David C., Wichmann, H. Erich, Widen, Elisabeth, Yao, Shuyang, Zeggini, Eleftheria, Zerwas, Stephanie, Zipfel, Stephan, Jungkunz, Martin, Dietl, Lydie, Schwarze, Cornelia E., Dahmen, Norbert, Schott, Björn H., Mobascher, Arian, Crivelli, Silvia, Dennis, Michelle F., Harvey, Phillip D., Carter, Bruce W., Huffman, Jennifer E., Jacobson, Daniel, Madduri, Ravi, Olsen, Maren K., Pestian, John, Gaziano, J. Michael, Muralidhar, Sumitra, Ramoni, Rachel, Beckham, Jean, Chang, Kyong-Mi, O’Donnell, Christopher J., Tsao, Philip, Breeling, James, Huang, Grant, Romero, J.P. Casas, Moser, Jennifer, Whitbourne, Stacey B., Brewer, Jessica V., Aslan, Mihaela, Connor, Todd, Argyres, Dean P., Stephens, Brady, Brophy, Mary T., Humphries, Donald E., Selva, Luis E., Do, Nhan, Shayan, Shahpoor, Cho, Kelly, Pyarajan, Saiju, Hauser, Elizabeth, Sun, Yan, Zhao, Hongyu, Wilson, Peter, McArdle, Rachel, Dellitalia, Louis, Mattocks, Kristin, Harley, John, Zablocki, Clement J., Whittle, Jeffrey, Jacono, Frank, Gutierrez, Salvador, Gibson, Gretchen, Hammer, Kimberly, Kaminsky, Laurence, Villareal, Gerardo, Kinlay, Scott, Xu, Junzhe, Hamner, Mark, Mathew, Roy, Bhushan, Sujata, Iruvanti, Pran, Godschalk, Michael, Ballas, Zuhair, Ivins, Douglas, Mastorides, Stephen, Moorman, Jonathan, Gappy, Saib, Klein, Jon, Ratcliffe, Nora, Florez, Hermes, Okusaga, Olaoluwa, Murdoch, Maureen, Sriram, Peruvemba, Yeh, Shing Shing, Tandon, Neeraj, Jhala, Darshana, Aguayo, Samuel, Cohen, David, Sharma, Satish, Liangpunsakul, Suthat, Oursler, Kris Ann, Whooley, Mary, Ahuja, Sunil, Constans, Joseph, Meyer, Paul, Greco, Jennifer, Rauchman, Michael, Servatius, Richard, Gaddy, Melinda, Wallbom, Agnes, Morgan, Timothy, Stapley, Todd, Sherman, Scott, Ross, George, Strollo, Patrick, Boyko, Edward, Meyer, Laurence, Gupta, Samir, Huq, Mostaqul, Fayad, Joseph, Hung, Adriana, Lichy, Jack, Hurley, Robin, Robey, Brooks, Striker, Robert, Erlangsen, Annette, Kessler, Ronald C., Porteous, David, Ursano, Robert J., Wasserman, Danuta, Coon, Hilary, Demontis, Ditte, Docherty, Anna R., Kuo, Po-Hsiu, Mann, J. John, Rentería, Miguel E., Stein, Murray B., Willour, Virginia

المساهمون: Institute for Molecular Medicine Finland, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, HUS Psychiatry, Department of Public Health, Clinicum, Nuorisopsykiatria, Faculty Common Matters (Faculty of Social Sciences), Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Biostatistics Helsinki, Anna Keski-Rahkonen / Principal Investigator, Elisabeth Ingrid Maria Widen / Principal Investigator, Genomic Discoveries and Clinical Translation

مصطلحات موضوعية: Genetic correlation, Genome-wide association study, Pleiotropy, Polygenicity, Suicide, Suicide attempt, 3124 Neurology and psychiatry

الوصف: Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders. ; Peer reviewed

وصف الملف: application/pdf

العلاقة: Mullins , N , Kang , J , Campos , A I , Coleman , J R I , Edwards , A C , Galfalvy , H , Levey , D F , Lori , A , Shabalin , A , Starnawska , A , Su , M-H , Watson , H J , Adams , M , Awasthi , S , Gandal , M , Hafferty , J D , Hishimoto , A , Kim , M , Okazaki , S , Otsuka , I , Ripke , S , Ware , E B , Bergen , A W , Berrettini , W H , Bohus , M , Brandt , H , Chang , X , Chen , W J , Chen , H-C , Crawford , S , Crow , S , DiBlasi , E , Duriez , P , Fernández-Aranda , F , Fichter , M M , Gallinger , S , Glatt , S J , Gorwood , P , Guo , Y , Hakonarson , H , Halmi , K A , Hwu , H-G , Jain , S , Jamain , S , Jiménez-Murcia , S , Johnson , C , Kaplan , A S , Kaye , W H , Keel , P K , Kennedy , J L , Klump , K L , Li , D , Liao , S-C , Lieb , K , Lilenfeld , L , Liu , C-M , Magistretti , P J , Marshall , C R , Mitchell , J E , Monson , E T , Myers , R M , Pinto , D , Powers , A , Ramoz , N , Roepke , S , Rozanov , V , Scherer , S W , Schmahl , C , Sokolowski , M , Strober , M , Thornton , L M , Treasure , J , Tsuang , M T , Witt , S H , Woodside , D B , Yilmaz , Z , Zillich , L , Adolfsson , R , Agartz , I , Air , T M , Alda , M , Alfredsson , L , Andreassen , O A , Anjorin , A , Appadurai , V , Soler Artigas , M , der Auwera , S V , Azevedo , M H , Bass , N , Bau , C H D , Baune , B T , Bellivier , F , Berger , K , Biernacka , J M , Bigdeli , T B , Binder , E B , Boehnke , M , Boks , M P , Bosch , R , Braff , D L , Bryant , R , Budde , M , Byrne , E M , Cahn , W , Casas , M , Castelao , E , Cervilla , J A , Chaumette , B , Cichon , S , Corvin , A , Craddock , N , Craig , D , Degenhardt , F , Djurovic , S , Edenberg , H J , Fanous , A H , Foo , J C , Forstner , A J , Frye , M , Fullerton , J M , Gatt , J M , Gejman , P V , Giegling , I , Grabe , H J , Green , M J , Grevet , E H , Grigoroiu-Serbanescu , M , Gutierrez , B , Guzman-Parra , J , Hamilton , S P , Hamshere , M L , Hartmann , A , Hauser , J , Heilmann-Heimbach , S , Hoffmann , P , Ising , M , Jones , I , Jones , L A , Jonsson , L , Kahn , R S , Kelsoe , J R , Kendler , K S , Kloiber , S , Koenen , K C , Kogevinas , M , Konte , B , Krebs , M-O , Landén , M , Lawrence , J , Leboyer , M , Lee , P H , Levinson , D F , Liao , C , Lissowska , J , Lucae , S , Mayoral , F , McElroy , S L , McGrath , P , McGuffin , P , McQuillin , A , Medland , S E , Mehta , D , Melle , I , Milaneschi , Y , Mitchell , P B , Molina , E , Morken , G , Mortensen , P B , Müller-Myhsok , B , Nievergelt , C M , Nimgaonkar , V , Nöthen , M M , O’Donovan , M C , Ophoff , R A , Owen , M J , Pato , C , Pato , M T , Penninx , B W J H , Pimm , J , Pistis , G , Potash , J B , Power , R A , Preisig , M , Quested , D , Ramos-Quiroga , J A , Reif , A , Ribasés , M , Richarte , V , Rietschel , M , Rivera , M , Roberts , A , Roberts , G , Rouleau , G A , Rovaris , D L , Rujescu , D , Sánchez-Mora , C , Sanders , A R , Schofield , P R , Schulze , T G , Scott , L J , Serretti , A , Shi , J , Shyn , S I , Sirignano , L , Sklar 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G , Wu , Y , Xi , S , Yang , J , Zhang , F , Arolt , V , Boomsma , D I , Dannlowski , U , de Geus , E J C , Depaulo , J R , Domenici , E , Domschke , K , Esko , T , Grove , J , Hall , L S , Hansen , C S , Hansen , T F , Herms , S , Hickie , I B , Homuth , G , Horn , C , Hottenga , J-J , Hougaard , D M , Howard , D M , Jansen , R , Jorgenson , E , Knowles , J A , Kohane , I S , Kraft , J , Kretzschmar , W W , Kutalik , Z , Li , Y , Lind , P A , MacIntyre , D J , MacKinnon , D F , Maier , R M , Maier , W , Marchini , J , Mbarek , H , Middeldorp , C M , Mihailov , E , Milani , L , Mondimore , F M , Montgomery , G W , Mostafavi , S , Nauck , M , Ng , B , Nivard , M G , Nyholt , D R , O’Reilly , P F , Oskarsson , H , Hayward , C , Heath , A C , Lewis , G , Li , Q S , Madden , P A F , Magnusson , P K , Martin , N G , McIntosh , A M , Metspalu , A , Mors , O , Nordentoft , M , Paciga , S A , Pedersen , N L , Painter , J N , Pedersen , C B , Pedersen , M G , Peterson , R E , Peyrot , W J , 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Loughland , C , Mathews , C A , McMahon , F J , Michie , P , Mowry , B , Neale , B M , Nievergelt , C M , Oedegaard , K J , Olsson , T , Pantelis , C , Patrinos , G P , Reininghaus , E Z , Saito , T , Schall , U , Schalling , M , Scott , R J , Weickert , C S , Stordal , E , Vaaler , A E , Vieta , E , Waldman , I D , Zwart , J-A , Nurnberger , J I , Stahl , E A , Di Florio , A , Adan , R A H , Ando , T , Aschauer , H , Baker , J H , Bencko , V , Birgegård , A , Boden , J M , Boehm , I , Boni , C , Perica , V B , Buehren , K , Bulik , C M , Burghardt , R , Carlberg , L , Cassina , M , Clementi , M , Cone , R D , Courtet , P , Crowley , J J , Danner , U N , Davis , O S P , de Zwaan , M , Dedoussis , G , Degortes , D , DeSocio , J E , Dick , D M , Dina , C , Dmitrzak-Weglarz , M , Martinez , E D , Duncan , L E , Egberts , K , Mattingsdal , M , McDevitt , S , Meulenbelt , I , Micali , N , Mitchell , J , Mitchell , K , Monteleone , P , Monteleone , A M , Munn-Chernoff , M A , Nacmias , B , 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, Sherman , S , Ross , G , Tsao , P , Strollo , P , Boyko , E , Meyer , L , Gupta , S , Huq , M , Fayad , J , Hung , A , Lichy , J , Hurley , R , Robey , B , Striker , R , Erlangsen , A , Kessler , R C , Porteous , D , Ursano , R J , Wasserman , D , Coon , H , Demontis , D , Docherty , A R , Kuo , P-H , Mann , J J , Rentería , M E , Stein , M B & Willour , V 2022 , ' Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors ' , Biological Psychiatry , vol. 91 , no. 3 , pp. 313-327 . https://doi.org/10.1016/j.biopsych.2021.05.029Test; RIS: urn:E69B9D5FB01AD733DC63F5023565B52F; ORCID: /0000-0002-2527-5874/work/106787135; ORCID: /0000-0001-7704-9441/work/106788120; ORCID: /0000-0002-6713-7488/work/106791225; f4480e1c-0fda-4c2d-a196-5a8bb85cf940; http://hdl.handle.net/10138/338669Test

الإتاحة: http://hdl.handle.net/10138/338669Test

المؤلفون: Mullins, Niamh, Kang, JooEun, Campos, Adrian I., Coleman, Jonathan R.I., Edwards, Alexis C., Galfalvy, Hanga, Levey, Daniel F., Lori, Adriana, Shabalin, Andrey, Starnawska, Anna, Su, Mei-Hsin, Watson, Hunna J., Adams, Mark, Awasthi, Swapnil, Gandal, Michael, Hafferty, Jonathan D., Hishimoto, Akitoyo, Kim, Minsoo, Okazaki, Satoshi, Otsuka, Ikuo, Ripke, Stephan, Ware, Erin B., Bergen, Andrew W., Berrettini, Wade H., Bohus, Martin, Brandt, Harry, Chang, Xiao, Chen, Wei J., Chen, Hsi-Chung, Crawford, Steven, Crow, Scott, DiBlasi, Emily, Duriez, Philibert, Fernández-Aranda, Fernando, Fichter, Manfred M., Gallinger, Steven, Glatt, Stephen J., Gorwood, Philip, Guo, Yiran, Hakonarson, Hakon, Halmi, Katherine A., Hwu, Hai-Gwo, Jain, Sonia, Jamain, Stéphane, Jiménez-Murcia, Susana, Johnson, Craig, Kaplan, Allan S., Kaye, Walter H., Keel, Pamela K., Kennedy, James L., Klump, Kelly L., Li, Dong, Liao, Shih-Cheng, Lieb, Klaus, Lilenfeld, Lisa, Liu, Chih-Min, Magistretti, Pierre J., Marshall, Christian R., Mitchell, James E., Monson, Eric T., Myers, Richard M., Pinto, Dalila, Powers, Abigail, Ramoz, Nicolas, Roepke, Stefan, Rozanov, Vsevolod, Scherer, Stephen W., Schmahl, Christian, Sokolowski, Marcus, Strober, Michael, Thornton, Laura M., Treasure, Janet, Tsuang, Ming T., Witt, Stephanie H., Woodside, D. Blake, Yilmaz, Zeynep, Zillich, Lea, Adolfsson, Rolf, Agartz, Ingrid, Air, Tracy M., Alda, Martin, Alfredsson, Lars, Andreassen, Ole A., Anjorin, Adebayo, Appadurai, Vivek, Soler Artigas, María, der Auwera, Sandra Van, Azevedo, M. 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John, Rentería, Miguel E., Stein, Murray B., Willour, Virginia

المساهمون: Institute for Molecular Medicine Finland, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, HUS Psychiatry, Department of Public Health, Clinicum, Nuorisopsykiatria, Faculty Common Matters (Faculty of Social Sciences), Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Biostatistics Helsinki, Anna Keski-Rahkonen / Principal Investigator, Elisabeth Ingrid Maria Widen / Principal Investigator, Genomic Discoveries and Clinical Translation

مصطلحات موضوعية: Genetic correlation, Genome-wide association study, Pleiotropy, Polygenicity, Suicide, Suicide attempt, 3124 Neurology and psychiatry, psy, socio

الوصف: Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders. ; Peer reviewed

العلاقة: http://hdl.handle.net/10138/338669Test

الإتاحة: http://hdl.handle.net/10138/338669Test