المؤلفون: Báltica Cabieses, John Wright, Josep M. Antó, Mariona Pinart, Eleonora Uphoff, Macarena Valdés

المصدر: European Respiratory Journal. 46:364-374

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pediatrics, Allergy, business.industry, Prevalence, Atopic dermatitis, Odds ratio, Disease, medicine.disease, Asthma, Dermatitis, Atopic, body regions, Social Class, Hygiene hypothesis, Risk Factors, Internal medicine, Odds Ratio, medicine, Humans, Hay fever, business, Conjunctivitis, Allergic

الوصف: The role of socioeconomic position (SEP) in the development of asthma and allergies is unclear, with some pointing to the risks of low SEP and other research pointing in the direction of higher SEP being associated with higher prevalence rates. The aim of this systematic review is to clarify associations between SEP and the prevalence of asthma and allergies. Out of 4407 records identified, 183 were included in the analysis. Low SEP was associated with a higher prevalence of asthma in 63% of the studies. Research on allergies, however, showed a positive association between higher SEP and illness in 66% of studies. Pooled estimates for the odds ratio of disease for the highest compared with the lowest SEP confirmed these results for asthma (unadjusted OR 1.38, 95% CI 1.37–1.39), allergies in general (OR 0.67, 95% CI 0.62–0.72), atopic dermatitis (unadjusted OR 0.72, 95% CI 0.61–0.83) and allergic rhinoconjunctivitis (unadjusted OR 0.52, 95% CI 0.46–0.59). Sensitivity analyses with a subsample of high-quality studies led to the same conclusion. Evidence from this systematic review suggests that asthma is associated with lower SEP, whereas the prevalence of allergies is associated with higher SEP.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712bc610eeded9b12a2f766b748c88a9Test
https://doi.org/10.1183/09031936.00114514Test

المؤلفون: M. Arfan Ikram, George Davey Smith, Augusto A. Litonjua, Josep M. Antó, Ivana Nedeljkovic, Mariona Bustamante, Herman T. den Dekker, Dawn L. DeMeo, Mariona Pinart, Caroline L Relton, A. John Henderson, Gemma C Sharp, Jin Yao, Lucas A. Salas, Carlos Ruiz-Arenas, André G. Uitterlinden, Janine F. Felix, Liesbeth Duijts, Johan C. de Jongste, Marie-France Hivert, Jordi Sunyer, Caitlin G. Howe, Lies Lahousse, Carrie V. Breton, Guy Brusselle, Najaf Amin, Vincent W. V. Jaddoe, Sheryl L. Rifas-Shiman, Lisette Stolk, Joyce B. J. van Meurs, Kimberley Burrows, Pooja R. Mandaviya

المساهمون: Maastricht Centre for Systems Biology, RS: FSE MaCSBio, Erasmus MC other, Pediatrics, Epidemiology, Clinical Chemistry, Internal Medicine, Pulmonary Medicine

المصدر: European Respiratory Journal
European Respiratory Journal, 53(4):1801795. European Respiratory Society
den Dekker, H T, Burrows, K, Felix, J F, Salas, L A, Nedeljkovic, I, Yao, J, Rifas-Shiman, S L, Ruiz-Arenas, C, Amin, N, Bustamante, M, DeMeo, D L, John Henderson, A, Howe, C G, Hivert, M-F, Arfan Ikram, M, de Jongste, J C, Lahousse, L, Mandaviya, P R, van Meurs, J B, Pinart, M, Sharp, G C, Stolk, L, Uitterlinden, A G, Anto, J M, Litonjua, A A, Breton, C V, Brusselle, G G, Sunyer, J, Smith, G D, Relton, C L, Jaddoe, V W V & Duijts, L 2019, ' Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course ', European Respiratory Journal, vol. 53, no. 4, 1801795 . https://doi.org/10.1183/13993003.01795-2018Test

مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Vital capacity, Adolescent, Vital Capacity, Disease, OBSTRUCTIVE PULMONARY-DISEASE, Risk Assessment, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, Forced Expiratory Volume, Internal medicine, medicine, Humans, CORD BLOOD, PREDICTORS, Child, Asthma, COPD, business.industry, Infant, Newborn, ALSPAC, DNA Methylation, medicine.disease, respiratory tract diseases, 030104 developmental biology, Differentially methylated regions, 030228 respiratory system, ORIGINS, Cord blood, DNA methylation, PATTERNS, business

الوصف: RationaleWe aimed to identify differentially methylated regions (DMRs) in cord blood DNA associated with childhood lung function, asthma and chronic obstructive pulmonary disease (COPD) across the life course.MethodsWe meta-analysed epigenome-wide data of 1688 children from five cohorts to identify cord blood DMRs and their annotated genes, in relation to forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC) ratio and forced expiratory flow at 75% of FVC at ages 7–13 years. Identified DMRs were explored for associations with childhood asthma, adult lung function and COPD, gene expression and involvement in biological processes.ResultsWe identified 59 DMRs associated with childhood lung function, of which 18 were associated with childhood asthma and nine with COPD in adulthood. Genes annotated to the top 10 identified DMRs were HOXA5, PAOX, LINC00602, ABCA7, PER3, CLCA1, VENTX, NUDT12, PTPRN2 and TCL1A. Differential gene expression in blood was observed for 32 DMRs in childhood and 18 in adulthood. Genes related with 16 identified DMRs were associated with respiratory developmental or pathogenic pathways.InterpretationOur findings suggest that the epigenetic status of the newborn affects respiratory health and disease across the life course.

وصف الملف: application/zip; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d772427709419ba5cf858d1aa031db1Test
https://doi.org/10.1183/13993003.01795-2018Test