Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course
| العنوان: | Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course |
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| المؤلفون: | M. Arfan Ikram, George Davey Smith, Augusto A. Litonjua, Josep M. Antó, Ivana Nedeljkovic, Mariona Bustamante, Herman T. den Dekker, Dawn L. DeMeo, Mariona Pinart, Caroline L Relton, A. John Henderson, Gemma C Sharp, Jin Yao, Lucas A. Salas, Carlos Ruiz-Arenas, André G. Uitterlinden, Janine F. Felix, Liesbeth Duijts, Johan C. de Jongste, Marie-France Hivert, Jordi Sunyer, Caitlin G. Howe, Lies Lahousse, Carrie V. Breton, Guy Brusselle, Najaf Amin, Vincent W. V. Jaddoe, Sheryl L. Rifas-Shiman, Lisette Stolk, Joyce B. J. van Meurs, Kimberley Burrows, Pooja R. Mandaviya |
| المساهمون: | Maastricht Centre for Systems Biology, RS: FSE MaCSBio, Erasmus MC other, Pediatrics, Epidemiology, Clinical Chemistry, Internal Medicine, Pulmonary Medicine |
| المصدر: | European Respiratory Journal European Respiratory Journal, 53(4):1801795. European Respiratory Society den Dekker, H T, Burrows, K, Felix, J F, Salas, L A, Nedeljkovic, I, Yao, J, Rifas-Shiman, S L, Ruiz-Arenas, C, Amin, N, Bustamante, M, DeMeo, D L, John Henderson, A, Howe, C G, Hivert, M-F, Arfan Ikram, M, de Jongste, J C, Lahousse, L, Mandaviya, P R, van Meurs, J B, Pinart, M, Sharp, G C, Stolk, L, Uitterlinden, A G, Anto, J M, Litonjua, A A, Breton, C V, Brusselle, G G, Sunyer, J, Smith, G D, Relton, C L, Jaddoe, V W V & Duijts, L 2019, ' Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course ', European Respiratory Journal, vol. 53, no. 4, 1801795 . https://doi.org/10.1183/13993003.01795-2018Test |
| بيانات النشر: | European Respiratory Society (ERS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Vital capacity, Adolescent, Vital Capacity, Disease, OBSTRUCTIVE PULMONARY-DISEASE, Risk Assessment, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, Forced Expiratory Volume, Internal medicine, medicine, Humans, CORD BLOOD, PREDICTORS, Child, Asthma, COPD, business.industry, Infant, Newborn, ALSPAC, DNA Methylation, medicine.disease, respiratory tract diseases, 030104 developmental biology, Differentially methylated regions, 030228 respiratory system, ORIGINS, Cord blood, DNA methylation, PATTERNS, business |
| الوصف: | RationaleWe aimed to identify differentially methylated regions (DMRs) in cord blood DNA associated with childhood lung function, asthma and chronic obstructive pulmonary disease (COPD) across the life course.MethodsWe meta-analysed epigenome-wide data of 1688 children from five cohorts to identify cord blood DMRs and their annotated genes, in relation to forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC) ratio and forced expiratory flow at 75% of FVC at ages 7–13 years. Identified DMRs were explored for associations with childhood asthma, adult lung function and COPD, gene expression and involvement in biological processes.ResultsWe identified 59 DMRs associated with childhood lung function, of which 18 were associated with childhood asthma and nine with COPD in adulthood. Genes annotated to the top 10 identified DMRs were HOXA5, PAOX, LINC00602, ABCA7, PER3, CLCA1, VENTX, NUDT12, PTPRN2 and TCL1A. Differential gene expression in blood was observed for 32 DMRs in childhood and 18 in adulthood. Genes related with 16 identified DMRs were associated with respiratory developmental or pathogenic pathways.InterpretationOur findings suggest that the epigenetic status of the newborn affects respiratory health and disease across the life course. |
| وصف الملف: | application/zip; application/pdf |
| تدمد: | 1399-3003 0903-1936 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d772427709419ba5cf858d1aa031db1Test https://doi.org/10.1183/13993003.01795-2018Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2d772427709419ba5cf858d1aa031db1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13993003 09031936 |
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