Molecular surveillance of pandemic influenza A(H1N1) viruses circulating in Italy from May 2009 to February 2010: association between haemagglutinin mutations and clinical outcome
| العنوان: | Molecular surveillance of pandemic influenza A(H1N1) viruses circulating in Italy from May 2009 to February 2010: association between haemagglutinin mutations and clinical outcome |
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| المؤلفون: | Puzelli, S, Facchini, M, De Marco, M. A, Palmieri, A, Spagnolo, D, Boros, S, Corcioli, F, Trotta, D, Bagnarelli, P, Azzi, Anna, Cassone, A, Rezza, G, Pompa, M. G, Oleari, F, Donatelli, I, Capobianchi, Mr, Fadda, Giuseppe, Palu', Giorgio, Vitale, F, D'Agaro, P, Esposito, C, Ghisetti, V, Ansaldi, F, Zanetti, A, Nelli, Lc, Baldanti, F. |
| المساهمون: | Puzelli, S., Facchini, M., De Marco, M. A., Palmieri, A., Spagnolo, D., Boros, S., Corcioli, F., Trotta, D., Bagnarelli, P., Azzi, A., Cassone, A., Rezza, G., Pompa, M. G., Oleari, F., Donatelli, I., Influnet Surveillance Group for Pandemic A., 2009 Influenza Virus in Italy, D'Agaro, Pierlanfranco, Puzelli, S, Facchini, M, De Marco, MA, Palmieri, A, Spagnolo, D, Boros, S, Corcioli, F, Trotta, D, Bagnarelli, P, Azzi, A, Cassone, A, Rezza, G, Pompa, MG, Oleari, F, Donatelli, I, Vitale, F |
| المصدر: | Eurosurveillance. 15 |
| بيانات النشر: | European Centre for Disease Control and Prevention (ECDC), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Molecular surveillance, Pandemic influenza A(H1N1), Haemagglutinin mutations, Italy from May 2009 to February 2010, pandemic influenza, surveillance of pandemic influenza A(H1N1), Epidemiology, viruses, Settore MED/42 - Igiene Generale E Applicata, medicine.disease_cause, Severity of Illness Index, Influenza A Virus, H1N1 Subtype, Pandemic, Influenza A Virus, A(H1N1), Child, Mutation, Reverse Transcriptase Polymerase Chain Reaction, Transmission (medicine), Adolescent, Adult, Age Distribution, Aged, Amino Acid Substitution, Child, Preschool, Female, Hemagglutinins, Humans, Infant, Influenza, Human, Italy, Middle Aged, Population Surveillance, Sex Distribution, Young Adult, Pandemics, haemagglutinin mutations, Human, Biology, Disease cluster, Disease course, Virology, medicine, H1N1 Subtype, Preschool, Molecular epidemiology, Public Health, Environmental and Occupational Health, Pandemic influenza, Influenza, Mutational analysis |
| الوصف: | Haemagglutinin sequences of pandemic influenza A(H1N1) viruses circulating in Italy were examined, focusing on amino acid changes at position 222 because of its suggested pathogenic relevance. Among 169 patients, the D222G substitution was detected in three of 52 (5.8%) severe cases and in one of 117 (0.9%) mild cases, whereas the D222E mutation was more frequent and evenly distributed in mild (31.6%) and severe cases (38.4%). A cluster of D222E viruses among school children confirms reported human-to-human transmission of viruses mutated at amino acid position 222. |
| وصف الملف: | ELETTRONICO |
| تدمد: | 1560-7917 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef43070a21147e7d7e48688ad43473fTest https://doi.org/10.2807/ese.15.43.19696-enTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4ef43070a21147e7d7e48688ad43473f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15607917 |
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