Pre- and Postnatal Arsenic Exposure and Body Size to 2 Years of Age: A Cohort Study in Rural Bangladesh
| العنوان: | Pre- and Postnatal Arsenic Exposure and Body Size to 2 Years of Age: A Cohort Study in Rural Bangladesh |
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| المؤلفون: | Annette Engström, Kathleen M. Rasmussen, Marie Vahter, Kuntal K. Saha, Jena D. Hamadani, Fahmida Tofail |
| المصدر: | Environmental Health Perspectives |
| بيانات النشر: | Environmental Health Perspectives, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Rural Population, inorganic chemicals, Pediatrics, medicine.medical_specialty, arsenic exposure, Health, Toxicology and Mutagenesis, maternal urine, chemistry.chemical_element, Body size, Arsenic, Cohort Studies, Environmental health, medicine, Body Size, Humans, Socioeconomic status, Bangladesh, Pregnancy, integumentary system, business.industry, Research, drinking water, Public Health, Environmental and Occupational Health, Infant, Environmental Exposure, Environmental exposure, medicine.disease, MINIMat, child growth, chemistry, Child, Preschool, Female, pregnancy, Rural area, business, Body mass index, Cohort study |
| الوصف: | Background: Exposure to arsenic via drinking water has been associated with adverse pregnancy outcomes and infant morbidity and mortality. Little is known, however, about the effects of arsenic on child growth. Objective: We assessed potential effects of early-life arsenic exposure on weight and length of children from birth to 2 years of age. Methods: We followed 2,372 infants born in a population-based intervention trial in rural Bangladesh. Exposure was assessed by arsenic concentrations in urine (U-As) of mothers (gestational weeks 8 and 30) and children (18 months old). Child anthropometry was measured monthly in the first year and quarterly in the second. Linear regression models were used to examine associations of U-As (by quintiles) with child weight and length, adjusted for age, maternal body mass index, socioeconomic status, and sex (or stratified by sex). Results: Median (10th–90th percentiles) U-As concentrations were about 80 (25–400) µg/L in the mothers and 34 (12–159) µg/L in the children. Inverse associations of maternal U-As with child’s attained weight and length at 3–24 months were markedly attenuated after adjustment. However, associations of U-As at 18 months with weight and length at 18–24 months were more robust, particularly in girls. Compared with girls in the first quintile of U-As (< 16 µg/L), those in the fourth quintile (26–46 µg/L) were almost 300 g lighter and 0.7 cm shorter, and had adjusted odds ratios (95% confidence interval) for underweight and stunting of 1.57 (1.02–2.40) and 1.58 (1.05–2.37), respectively, at 21 months. Conclusions: Postnatal arsenic exposure was associated with lower body weight and length among girls, but not boys. |
| تدمد: | 1552-9924 0091-6765 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b338ebf02436e5e8bc3cdbbcd8e4f2fTest https://doi.org/10.1289/ehp.1003378Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2b338ebf02436e5e8bc3cdbbcd8e4f2f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15529924 00916765 |
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