Oral toxicity of 1,1-Dichloroethylene in the rat: Effects of sex, age, and fasting
| العنوان: | Oral toxicity of 1,1-Dichloroethylene in the rat: Effects of sex, age, and fasting |
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| المؤلفون: | Melvin E. Andersen, L.J. Jenkins |
| المصدر: | Environmental Health Perspectives |
| بيانات النشر: | Environmental Health Perspectives, 1977. |
| سنة النشر: | 1977 |
| مصطلحات موضوعية: | Male, L-Iditol 2-Dehydrogenase, medicine.medical_specialty, Injury control, Health, Toxicology and Mutagenesis, Administration, Oral, Poison control, L-Lactate dehydrogenase, Pharmacology, Median lethal dose, Lethal Dose 50, Sex Factors, Sex factors, Internal medicine, Male rats, Hydrocarbons, Chlorinated, medicine, Animals, Aspartate Aminotransferases, Oral toxicity, skin and connective tissue diseases, Dose-Response Relationship, Drug, L-Lactate Dehydrogenase, biology, business.industry, Age Factors, Public Health, Environmental and Occupational Health, Alanine Transaminase, Fasting, Articles, Dichloroethylenes, Rats, Endocrinology, Liver, Alanine transaminase, biology.protein, Female, Chemical and Drug Induced Liver Injury, business |
| الوصف: | Mortality curves for groups of fasted male rats treated with single, oral doses of 1,1-dichloroethylene (1,1-DCE, vinylidene chloride) were not monotonically increasing sigmoids, but were complex with maxima or extended plateaus in the region of dose between 100 and 700 mg of 1,1-DCE/kg. The exact shape was a function of the size (age) of the rat used. When groups of rats of various sizes were dosed with 50 mg/kg, mortality and hepatotoxicity were greatest for those groups whose average weight was between 100 and 150 g. Smaller and larger male rats were less susceptible to 1,1-DCE intoxication. The toxicity of 1,1-DCE was less severe in female rats and there was no significant effect of rat size on 1,1-DCE toxicity in females. In rats of both sexes the dose dependence of the hepatotoxic response was complex, possessing a threshold level, a region of precipitous increase, and a plateau, where larger doses were ineffective in increasing hepatotoxicity. The threshold in male rats of 100–150 g occurred near 50 mg/kg, and for females it was closer to 100 mg/kg. Considered in their entirety these data suggest that 1,1-DCE is metabolized to a toxic intermediate via some saturable pathway. Based on the effects of pretreatment with microsomal enzyme inhibitors and activators on 1,1-DCE toxicity in rats of various sizes, it appears that there are at least two microsomal reactions involved in 1,1-DCE metabolism. |
| تدمد: | 1552-9924 0091-6765 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46add6853a223d8cb4a5c33c5fee5bbTest https://doi.org/10.1289/ehp.7721157Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e46add6853a223d8cb4a5c33c5fee5bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15529924 00916765 |
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