Folic Acid Supplementation and the Association between Maternal Airborne Particulate Matter Exposure and Preterm Delivery: A National Birth Cohort Study in China
| العنوان: | Folic Acid Supplementation and the Association between Maternal Airborne Particulate Matter Exposure and Preterm Delivery: A National Birth Cohort Study in China |
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| المؤلفون: | Yuming Guo, Zuo Qi Peng, Qin Li, Hai Ping Shen, Qiao Mei Wang, Xiaobin Wang, Shanshan Li, Xu Ma, Hai-Jun Wang, Lizi Lin, Yuan He, Dong Hai Yan, Hong Zhou, Ying Yang, Yiping Zhang, Yuanyuan Wang, Gongbo Chen |
| المصدر: | Environmental Health Perspectives |
| بيانات النشر: | Environmental Health Perspectives, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | China, medicine.medical_specialty, Health, Toxicology and Mutagenesis, Clinical nutrition, 010501 environmental sciences, 01 natural sciences, 03 medical and health sciences, Folic Acid, 0302 clinical medicine, Air Pollution, Epidemiology, medicine, Humans, 030212 general & internal medicine, Preterm delivery, 0105 earth and related environmental sciences, Pregnancy, Obstetrics, business.industry, Research, Public Health, Environmental and Occupational Health, Particulates, medicine.disease, Folic acid supplementation, Folic acid, Maternal Exposure, Dietary Supplements, Premature Birth, Female, Particulate Matter, business, Birth cohort |
| الوصف: | Background: Potential modification of the association between maternal particulate matter (PM) exposure and preterm delivery (PTD) by folic acid (FA) supplementation has not been studied. Objective: We examined whether FA supplementation could reduce the risk of PTD associated with maternal exposure to PM in ambient air during pregnancy. Method: In a cohort study covering 30 of the 31 provinces of mainland China in 2014, 1,229,556 primiparas of Han ethnicity were followed until labor. We collected information on their FA supplementation and pregnancy outcomes and estimated each participant’s exposure to PM with diameters of ≤10μm (PM10), 2.5μm (PM2.5), and 1μm (PM1) using satellite remote-sensing based models. Cox proportional hazard regression models were used to examine interactions between FA supplementation and PM exposures, after controlling for individual characteristics. Results: Participants who initiated FA ≥3 months prior to pregnancy (38.1%) had a 23% [hazard ratio (HR)=0.77 (95% CI: 0.76, 0.78)] lower risk of PTD than women who did not use preconception FA. Participants with PM concentrations in the highest quartile had a higher risk of PTD [HR=1.29 (95% CI: 1.26, 1.32) for PM1, 1.52 (95% CI: 1.46, 1.58) for PM2.5, and 1.22 (95% CI: 1.17, 1.27) for PM10] than those with exposures in the lowest PM quartiles. Estimated associations with a 10-μg/m3 increase in PM1 and PM2.5 were significantly lower among women who initiated FA ≥3 months prior to pregnancy [HR=1.09 (95% CI: 1.08, 1.10) for both exposures] than among women who did not use preconception FA [HR=1.12 (95% CI: 1.11, 1.13) for both exposures; pinteraction |
| تدمد: | 1552-9924 0091-6765 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdf1601b658d5e26cc5cdf05172b718Test https://doi.org/10.1289/ehp6386Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0bdf1601b658d5e26cc5cdf05172b718 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15529924 00916765 |
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