دورية أكاديمية
Bone mineral health is sensitively related to environmental cadmium exposure- experimental and human data.
| العنوان: | Bone mineral health is sensitively related to environmental cadmium exposure- experimental and human data. |
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| المؤلفون: | Buha, Aleksandra, Jugdaohsingh, Ravin, Matovic, Vesna, Bulat, Zorica, Antonijevic, Biljana, Kerns, Jemma G, Goodship, Allen, Hart, Alister, Powell, Jonathan J |
| بيانات النشر: | Elsevier BV //dx.doi.org/10.1016/j.envres.2019.108539 Environ Res |
| سنة النشر: | 2019 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Bones, Cadmium, Human samples, Rats, Zinc, Animals, Bone Density, Bone and Bones, Environmental Exposure, Humans, Male, Minerals, Wistar |
| الوصف: | Exposure to cadmium (Cd) is recognised as one of the risk factors for osteoporosis, although critical exposure levels and exact mechanisms are still unknown. Here, we first confirmed that in male Wistar rats challenged orally with 6 different levels of Cd (0.3-10 mg/kg b.w.), over 28 days, there was a direct dose relationship to bone Cd concentration. Moreover, bone mineral content was significantly diminished by ∼15% (p < 0.0001) plateauing already at the lowest exposure level. For the other essential bone elements zinc (Zn) loss was most marked. Having established the sensitive metrics (measures of Cd exposure), we then applied them to 20 randomly selected human femoral head bone samples from 16 independent subjects. Bone Cd concentration was inversely proportional to trabecular bone mineral density and mineral (calcium) content and Zn content of bone, but not the donor's age. Our findings, through direct bone analyses, support the emerging epidemiological view that bone health, adjudged by mineral density, is extremely sensitive to even background levels of environmental Cd. Importantly, however, our data also suggest that Cd may play an even greater role in compromised bone health than prior indirect estimates of exposure could reveal. Environmental Cd may be a substantially determining factor in osteoporosis and large cohort studies with direct bone analyses are now merited. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; application/msword; application/octet-stream; image/jpeg |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/293734Test |
| DOI: | 10.17863/CAM.40848 |
| الإتاحة: | https://doi.org/10.17863/CAM.40848Test https://www.repository.cam.ac.uk/handle/1810/293734Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.26CF260C |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.40848 |
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