مورد إلكتروني
Co-expression of ghrelin and its receptor in pancreatic endocrine tumours
| العنوان: | Co-expression of ghrelin and its receptor in pancreatic endocrine tumours |
|---|---|
| بيانات النشر: | Endokrin tumörbiologi Molekylär och morfologisk patologi Klinisk kemi Biokemisk endokrinologi Endokrinkirurgi 2007 |
| تفاصيل مُضافة: | Ekeblad, Sara Lejonklou, Margareta Halin Grimfjärd, Per Johansson, Térèse Eriksson, Barbro Grimelius, Lars Stridsberg, Mats Stålberg, Peter Skogseid, Britt |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Objective Expression of ghrelin has been reported in pancreatic endocrine tumours, but data on ghrelin receptor protein expression are lacking. The aim of this study was to examine the ghrelin receptor, as well as ghrelin, in a selected series of these tumours, including multiple endocrine neoplasia 1 (MEN1) associated tumours, and to correlate data with clinical features including body mass index. Design Immunohistochemical detection of ghrelin and its receptor was performed on frozen tissue from 31 tumours: 9 MEN1 and 22 sporadic. Twenty tumours were analysed by quantitative PCR. Plasma ghrelin was assessed in 26 patients. Results Twenty-one (68%) of 31 tumours showed immunoreactivity for ghrelin (8/9 MEN1) and 19/20 expressed ghrelin mRNA. Ghrelin receptor protein was detected in 21/30 (70%) tumours (4/8 MEN1), and mRNA was detected in all analysed tumours. Insulinomas had significantly higher levels of receptor mRNA than other tumours. Five patients had elevated plasma ghrelin (> 2 SD above the control group mean). No significant difference in mean plasma ghrelin levels was found between patients (908 ± 569 ng/l) and controls (952 ± 164 ng/l). Mean BMI was 24·3 kg/m2. There was no association between ghrelin or receptor expression and survival. Conclusions We report the first immunohistochemical data on expression of the ghrelin receptor in pancreatic endocrine tumours: 70% of tumours in our material. Concomitant ghrelin and receptor expression was seen in 50% of tumours, indicating an autocrine loop. Ghrelin was expressed in 68% of tumours (8/9 MEN1). Despite frequent ghrelin expression, elevated circulating ghrelin is rare in these patients. |
| مصطلحات الفهرس: | endocrine tumours, ghrelin receptor protein, Medical and Health Sciences, Medicin och hälsovetenskap, Article in journal, info:eu-repo/semantics/article, text |
| DOI: | 10.1111.j.1365-2265.2006.02695.x |
| URL: | Clinical Endocrinology, 0300-0664, 2007, 66:1, s. 115-122 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| أرقام أخرى: | UPE oai:DiVA.org:uu-22172 doi:10.1111/j.1365-2265.2006.02695.x PMID 17201810 ISI:000242780500017 1235075642 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1235075642 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1111.j.1365-2265.2006.02695.x |
|---|