دورية أكاديمية
Systematic appraisal of lactose intolerance as cause of increased need for oral thyroxine
| العنوان: | Systematic appraisal of lactose intolerance as cause of increased need for oral thyroxine |
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| المؤلفون: | Miriam, Cellini, Maria, Giulia Santaguida, Ilenia, Gatto, Camilla, Virili, Susanna, Carlotta Del Duca, Nunzia, Brusca, Silvia, Capriello, Lucilla, Gargano, Marco, Centanni |
| المساهمون: | Cellini, Miriam, Santaguida, Maria Giulia, Gatto, Ilenia, Virili, Camilla, Del Duca, Susanna Carlotta, Brusca, Nunzia, Capriello, Silvia, Gargano, Lucilla, Centanni, Marco |
| بيانات النشر: | Endocrine Society |
| سنة النشر: | 2014 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | hypothyroidism, lactose, thyroxine |
| الوصف: | Context: An increased need for T4 has been described in patients with different gastrointestinal disorders. However, there is a lack of systematic studies assessing the need for T4 in hypothyroid patients with lactose intolerance, a widespread and often occult disorder. Objective: The objective of the study was to assess the replacement T4 dose required in hypothyroid patients with lactose intolerance. Design: This was a cohort study. Setting: The study was conducted at an outpatient endocrinology unit in a University Hospital. Patients: The replacement T4 dose has been analyzed, from 2009 to 2012, in 34 hypothyroid patients due to Hashimoto's thyroiditis and lactose intolerance and being noncompliant with a lactose-free diet. Main Outcome Measure: An individually tailored T4 dose was measured. Results: In all patients with isolated Hashimoto's thyroiditis, target TSH (median TSH 1.02 mU/L) was obtained at a median T4 dose of 1.31 μg/kg/d. In patients with lactose intolerance, only five of 34 patients reached the desired TSH (median TSH 0.83 mU/L) with a similar T4 dose (1.29μg/kg/d). In the remaining 29 patients, the T4 dose was progressively increased and the target TSH (median TSH 1.21 mU/L) was attained at a median T4 dose of 1.81 μg/kg/d (+38%, P<.0001). In six of these patients, other gastrointestinal disorders were diagnosed, and their median T4 requirement was higher (2.04 μg/kg/d; +55%; P < .0032). In the remaining 23 patients with isolated lactose intolerance, a median T4 dose of 1.72 μg/kg/d (+31% P < .0001) has been required to attain pharmacological thyroid homeostasis. Conclusions: These findings show that lactose intolerance significantly increased the need for oral T4 in hypothyroid patients. Copyright © 2014 by the Endocrine Society. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/24796930; info:eu-repo/semantics/altIdentifier/wos/WOS:000342341200007; volume:99; issue:8; firstpage:E1454; lastpage:E1458; numberofpages:5; journal:THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM; http://hdl.handle.net/11573/560972Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84905837003 |
| DOI: | 10.1210/jc.2014-1217 |
| الإتاحة: | https://doi.org/10.1210/jc.2014-1217Test http://hdl.handle.net/11573/560972Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EE198C78 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/jc.2014-1217 |
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