دورية أكاديمية
Oxytocin reverses ovariectomy-induced osteopenia and body fat gain.
| العنوان: | Oxytocin reverses ovariectomy-induced osteopenia and body fat gain. |
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| المؤلفون: | Beranger, Guillaume E, Pisani, Didier F, Castel, Julien, Djedaini, Mansour, Battaglia, Séverine, Amiaud, Jérôme, Boukhechba, Florian, Ailhaud, Gérard, Michiels, Jean-François, Heymann, Dominique, Luquet, Serge, Amri, Ez-Zoubir |
| المساهمون: | Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA) |
| المصدر: | ISSN: 0013-7227 ; Endocrinology ; https://hal.science/hal-00968717Test ; Endocrinology, 2014, 155 (4), pp.1340-52. ⟨10.1210/en.2013-1688⟩. |
| بيانات النشر: | HAL CCSD Endocrine Society |
| سنة النشر: | 2014 |
| المجموعة: | HAL Université Côte d'Azur |
| مصطلحات موضوعية: | [SDV.BDD]Life Sciences [q-bio]/Development Biology |
| الوصف: | International audience ; Osteoporosis and overweight/obesity constitute major worldwide public health burdens that are associated with aging. A high proportion of women develop osteoporosis and increased intraabdominal adiposity after menopause. which leads to bone fractures and metabolic disorders. There is no efficient treatment without major side effects for these 2 diseases. We previously showed that the administration of oxytocin (OT) normalizes ovariectomy-induced osteopenia and bone marrow adiposity in mice. Ovariectomized mice, used as an animal model mimicking menopause, were treated with OT or vehicle. Trabecular bone parameters and fat mass were analyzed using micro-computed tomography. Herein, we show that this effect on trabecular bone parameters was mediated through the restoration of osteoblast/osteoclast cross talk via the receptor activator of nuclear factor-κB ligand /osteoprotegerin axis. Moreover, the daily administration of OT normalized body weight and intraabdominal fat depots in ovariectomized mice. Intraabdominal fat mass is more sensitive to OT that sc fat depots, and this inhibitory effect is mediated through inhibition of adipocyte precursor's differentiation with a tendency to lower adipocyte size. OT treatment did not affect food intake, locomotors activity, or energy expenditure, but it did promote a shift in fuel utilization favoring lipid oxidation. In addition, the decrease in fat mass resulted from the inhibition of the adipose precursor's differentiation. Thus, OT constitutes an effective strategy for targeting osteopenia, overweight, and fat mass redistribution without any detrimental effects in a mouse model mimicking the menopause. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/24506069; hal-00968717; https://hal.science/hal-00968717Test; PUBMED: 24506069 |
| DOI: | 10.1210/en.2013-1688 |
| الإتاحة: | https://doi.org/10.1210/en.2013-1688Test https://hal.science/hal-00968717Test |
| رقم الانضمام: | edsbas.7D2DEF7C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/en.2013-1688 |
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