دورية أكاديمية
Adiponectin Represses Colon Cancer Cell Proliferation via AdipoR1-and-R2-Mediated AMPK Activation
| العنوان: | Adiponectin Represses Colon Cancer Cell Proliferation via AdipoR1-and-R2-Mediated AMPK Activation |
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| المؤلفون: | Kim, AY Kim, A. Young, Lee, YS Lee, Yun Sok, Kim, KH Kim, Kang Ho, Lee, JH Lee, Jae Ho, Lee, HK Lee, Hee Kyu, Jang, SH Jang, Su-Hwa, Kim, SE Kim, Seong-Eun, Lee, GY Lee, Gha Young, Lee, JW Lee, Joo-Won, Jung, SA Jung, Sung-Ae, Chung, HY Chung, Hee Yong, Jeong, S Jeong, Sunjoo, Kim, JB Kim, Jae Bum |
| بيانات النشر: | ENDOCRINE SOC |
| سنة النشر: | 2010 |
| المجموعة: | Korea Advanced Institute of Science and Technology: KOASAS - KAIST Open Access Self-Archiving System |
| مصطلحات موضوعية: | FATTY-ACID SYNTHASE, PROTEIN-KINASE, COLORECTAL-CANCER, BREAST-CANCER, PLASMA ADIPONECTIN, PROSTATE-CANCER, ENDOMETRIAL CARCINOMA, SERUM ADIPONECTIN, GASTRIC-CANCER, IN-VIVO |
| الوصف: | In obesity, dysregulation of adipocytokines is involved in several pathological conditions including diabetes and certain cancers. As a member of the adipocytokines, adiponectin plays crucial roles in whole-body energy homeostasis. Recently, it has been reported that the level of plasma adiponectin is reduced in several types of cancer patients. However, it is largely unknown whether and how adiponectin affects colon cancer cell growth. Here, we show that adiponectin suppresses the proliferation of colon cancer cells including HCT116, HT29, and LoVo. In colon cancer cells, adiponectin attenuated cell cycle progression at the G(1)/S boundary and concurrently increased expression of cyclin-dependent kinase inhibitors such as p21 and p27. Adiponectin stimulated AMP-activated protein kinase (AMPK) phosphorylation whereas inhibition of AMPK activity blunted the effect of adiponectin on the proliferation of colon cancer cells. Furthermore, knock-down of adiponectin receptors such as AdipoR1 and AdipoR2 relieved the suppressive effect of adiponectin on the growth of colon cancer cells. In addition, adiponectin repressed the expression of sterol regulatory element binding protein-1c, which is a key lipogenic transcription factor associated with colon cancers. These results suggest that adiponectin could inhibit the growth of colon cancer cells through stimulating AMPK activity. (Molecular Endocrinology 24: 1441-1452, 2010) |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1210/me.2009-0498 |
| الإتاحة: | https://doi.org/10.1210/me.2009-0498Test http://hdl.handle.net/10203/198372Test |
| رقم الانضمام: | edsbas.A1639D1E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/me.2009-0498 |
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