دورية أكاديمية
Transfer of extracellular vesicle‐micro controls germinal center reaction and antibody production
| العنوان: | Transfer of extracellular vesicle‐micro controls germinal center reaction and antibody production |
|---|---|
| المؤلفون: | Fernández Messina, Lola María, Rodríguez‐Galán, Ana, Yébenes, Virginia G. de, Gutiérrez‐Vázquez, Cristina, Tenreiro, Sandra, Seabra, Miguel C., Ramiro, Almudena R., Sánchez‐Madrid, Francisco |
| بيانات النشر: | EMBO Press |
| سنة النشر: | 2020 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | 577.1, 577.2, 612.017, antibody production, exosomes, extracellular vesicles, germinal center (GC) reaction, microRNAs, Biología celular (Biología), Biología molecular (Biología), Bioquímica (Biología), Inmunología, 2407 Biología Celular, 2415 Biología Molecular, 2412 Inmunología |
| الوقت: | 576 |
| الوصف: | Acknowledgements NGS experiments were performed in the CNIC Genomics Unit (Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain) and analyzed by the CNIC Bioinformatics Unit. We thank Dr. Miguel Vicente‐Manzanares for critical reading of the manuscript and Dr. Henar Suárez and Dr. María Yañez‐Mó for their help with SEC experiments. This manuscript was funded by grants SAF 2017‐82886‐R (FS‐M) from the Spanish Ministry of Economy and Competitiveness; CAM (S2017/BMD‐3671‐INFLAMUNE‐CM) from the Comunidad de Madrid (FS‐M); CIBERCV (CB16/11/00272), BIOIMID PIE13/041 from the Instituto de Salud Carlos III and from the Fundación La Marató TV3 (grant 122/C/2015). The current research has received funding from “la Caixa” Foundation under the project code HR17‐00016. VGY is supported by the AECC foundation. A.R.R. is supported by CNIC funding. This project was funded by the Spanish Ministerio de Ciencia, Innovacion y Universidades SAF2016‐75511‐R, and La Caixa Health Research Program HR17‐00247 grant to A.R.R. Grants from Ramón Areces Foundation “Ciencias de la Vida y de la Salud” (XIX Concurso‐2018) and from Ayuda Fundación BBVA y Equipo de Investigación Científica (BIOMEDICINA‐2018) (to FSM). The CNIC is supported by the Ministerio de Ciencia, Innovacion y Universidades and the Pro‐CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV‐2015‐0505). ; Intercellular communication orchestrates effective immune responses against disease-causing agents. Extracellular vesicles (EVs) are potent mediators of cell-cell communication. EVs carry bioactive molecules, including microRNAs, which modulate gene expression and function in the recipient cell. Here, we show that formation of cognate primary T-B lymphocyte immune contacts promotes transfer of a very restricted set of T-cell EV-microRNAs (mmu-miR20-a-5p, mmu-miR-25-3p, and mmu-miR-155-3p) to the B cell. Transferred EV-microRNAs target key genes that control B-cell function, including pro-apoptotic BIM and the cell cycle regulator PTEN. EV-microRNAs ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1469-221X 1469-3178 |
| العلاقة: | SAF 2017‐82886‐R; S2017/BMD‐3671‐INFLAMUNE‐CM; info:eu-repo/grantAgreement/MINECO//CB16%2F11%2F00272/ES/ENFERMEDADES CARDIOVASCULARES/; PIE13/041; Fundación La Marató TV3 (grant 122/C/2015); HR17‐00016; https://hdl.handle.net/20.500.14352/97225Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132182Test/ |
| DOI: | 10.15252/embr.201948925 |
| الإتاحة: | https://doi.org/20.500.14352/97225Test https://doi.org/10.15252/embr.201948925Test https://hdl.handle.net/20.500.14352/97225Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132182Test/ |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.52E99808 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1469221X 14693178 |
|---|---|
| DOI: | 10.15252/embr.201948925 |