دورية أكاديمية
In vivo expansion of functionally integrated GABAergic interneurons by targeted increase in neural progenitors.
| العنوان: | In vivo expansion of functionally integrated GABAergic interneurons by targeted increase in neural progenitors. |
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| المؤلفون: | Shaw, Rachel E, Kottler, Benjamin, Ludlow, Zoe N, Buhl, Edgar, Kim, Dongwook, Morais da Silva, Sara, Miedzik, Alina, Coum, Antoine, Hodge, James Jl, Hirth, Frank, Sousa-Nunes, Rita |
| بيانات النشر: | Springer Science and Business Media LLC //dx.doi.org/10.15252/embj.201798163 EMBO J |
| سنة النشر: | 2018 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Prospero, circuit plasticity, evolutionary neurobiology, lineage expansion, neural stem cells, Animals, Biological Evolution, Brain, Drosophila, Drosophila Proteins, Female, GABAergic Neurons, Interneurons, Male, Nerve Tissue Proteins, Nuclear Proteins, Transcription Factors |
| الوصف: | A central hypothesis for brain evolution is that it might occur via expansion of progenitor cells and subsequent lineage-dependent formation of neural circuits. Here, we report in vivo amplification and functional integration of lineage-specific circuitry in Drosophila Levels of the cell fate determinant Prospero were attenuated in specific brain lineages within a range that expanded not only progenitors but also neuronal progeny, without tumor formation. Resulting supernumerary neural stem cells underwent normal functional transitions, progressed through the temporal patterning cascade, and generated progeny with molecular signatures matching source lineages. Fully differentiated supernumerary gamma-amino butyric acid (GABA)-ergic interneurons formed functional connections in the central complex of the adult brain, as revealed by in vivo calcium imaging and open-field behavioral analysis. Our results show that quantitative control of a single transcription factor is sufficient to tune neuron numbers and clonal circuitry, and provide molecular insight into a likely mechanism of brain evolution. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/279720Test |
| DOI: | 10.17863/CAM.27091 |
| الإتاحة: | https://doi.org/10.17863/CAM.27091Test https://www.repository.cam.ac.uk/handle/1810/279720Test |
| حقوق: | Attribution 4.0 International (CC BY 4.0) ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.E8348D51 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.27091 |
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