دورية أكاديمية
Embryo-uterine interaction coordinates mouse embryogenesis during implantation
| العنوان: | Embryo-uterine interaction coordinates mouse embryogenesis during implantation |
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| المؤلفون: | Bondarenko, Vladyslav, Nikolaev, Mikhail, Kromm, Dimitri, Belousov, Roman, Wolny, Adrian, Blotenburg, Marloes, Zeller, Peter, Rezakhani, Saba, Hugger, Johannes, Uhlmann, Virginie, Hufnagel, Lars, Kreshuk, Anna, Ellenberg, Jan, van Oudenaarden, Alexander, Erzberger, Anna, Lutolf, Matthias P, Hiiragi, Takashi |
| المساهمون: | 柊, 卓志 |
| بيانات النشر: | EMBO |
| سنة النشر: | 2023 |
| المجموعة: | Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ |
| مصطلحات موضوعية: | biophysical modeling, embryo, engineering, Implantation, uterus |
| الوصف: | Embryo implantation into the uterus marks a key transition in mammalian development. In mice, implantation is mediated by the trophoblast and is accompanied by a morphological transition from the blastocyst to the egg cylinder. However, the roles of trophoblast‐uterine interactions in embryo morphogenesis during implantation are poorly understood due to inaccessibility in utero and the remaining challenges to recapitulate it ex vivo from the blastocyst. Here, we engineer a uterus‐like microenvironment to recapitulate peri‐implantation development of the whole mouse embryo ex vivo and reveal essential roles of the physical embryo‐uterine interaction. We demonstrate that adhesion between the trophoblast and the uterine matrix is required for in utero‐like transition of the blastocyst to the egg cylinder. Modeling the implanting embryo as a wetting droplet links embryo shape dynamics to the underlying changes in trophoblast adhesion and suggests that the adhesion‐mediated tension release facilitates egg cylinder formation. Light‐sheet live imaging and the experimental control of the engineered uterine geometry and trophoblast velocity uncovers the coordination between trophoblast motility and embryo growth, where the trophoblast delineates space for embryo morphogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0261-4189 1460-2075 |
| العلاقة: | http://hdl.handle.net/2433/286482Test; The EMBO Journal; 42; 17; e113280 |
| الإتاحة: | http://hdl.handle.net/2433/286482Test |
| حقوق: | © 2023 The Authors. ; Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.B2CD7850 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02614189 14602075 |
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