FIP200 regulates targeting of Atg16L1 to the isolation membrane
| العنوان: | FIP200 regulates targeting of Atg16L1 to the isolation membrane |
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| المؤلفون: | Herbert W. Virgin, Shizuo Akira, Noboru Mizushima, Taki Nishimura, Tatsuya Saitoh, Mayurbhai Himatbhai Sahani, Takeshi Kaizuka, Ken Cadwell |
| المصدر: | EMBO reports. 14:284-291 |
| بيانات النشر: | EMBO, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Autophagosome, Deletion mutant, Vesicular Transport Proteins, Autophagy-Related Proteins, Biology, Biochemistry, Mice, chemistry.chemical_compound, Isolation membrane, Autophagy, Genetics, Animals, Humans, Protein Interaction Domains and Motifs, Phosphatidylinositol, Molecular Biology, ATG16L1, Cell Membrane, Scientific Reports, Intracellular Signaling Peptides and Proteins, ULK1, Cell biology, Protein Transport, HEK293 Cells, Membrane, chemistry, Phosphatidylinositol 3-Kinase, Carrier Proteins, Gene Deletion, Protein Binding |
| الوصف: | Autophagosome formation is a dynamic process that is strictly controlled by autophagy-related (Atg) proteins. However, how these Atg proteins are recruited to the autophagosome formation site or autophagic membranes remains poorly understood. Here, we found that FIP200, which is involved in proximal events, directly interacts with Atg16L1, one of the downstream Atg factors, in an Atg14- and phosphatidylinositol 3-kinase-independent manner. Atg16L1 deletion mutants, which lack the FIP200-interacting domain, are defective in proper membrane targeting. Thus, FIP200 regulates not only early events but also late events of autophagosome formation through direct interaction with Atg16L1. |
| تدمد: | 1469-3178 1469-221X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae51e651ae48ab94c1b8ce78de0a6f6Test https://doi.org/10.1038/embor.2013.6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cae51e651ae48ab94c1b8ce78de0a6f6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14693178 1469221X |
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