Sub-acute effect of NG-nitro-l-arginine methyl-ester (L-NAME) on biochemical indices ins rats: Protective effects of Kolaviron and extract of Curcuma longa L
التفاصيل البيبلوغرافية
العنوان:
Sub-acute effect of NG-nitro-l-arginine methyl-ester (L-NAME) on biochemical indices ins rats: Protective effects of Kolaviron and extract of Curcuma longa L
Background: Kolaviron (KV) (biflavonoid from Garcinia kola) and extract of Curcuma longa (CL) are frequently used in folk medicine for treatment of hypertension. One of their mechanisms of action is to enhance antioxidant properties in animals. NG - nitro- l- arginine methyl- ester (L- NAME) is L- arginine analogue, which by binding to Nitric Oxide Synthase (NOS) may induce hypertension partly due to increase in tissues oxidative stress. Objectives: To investigate the effect of L- NAME on some biochemical indices and the possible protective effect of KV or CL. Materials and Methods: Four groups consisting of 6 rats each were used. One group served as control, second group received L- NAME (40 mg/kg/day). Third and fourth groups were treated with KV and CL, respectively and also received L- NAME. KV and CL were given at a dose of 200 mg/kg/day. Results: L- NAME caused a significant (P
