دورية أكاديمية
Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards
| العنوان: | Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards |
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| المؤلفون: | Marcucci, M, Iorio, A, Nobili, A, Tettamanti, M, Pasina, L, Marengoni, A, Salerno, F, Mannucci, PM, Tedeschi, A, Rossio, R, Moreo, G, Ferrari, B, Mammarella, A, Raparelli, V, Rondinella, S, Giannico, I, Rasciti, L, Gualandi, S, Monzani, V, Savojardo, V, Fabio, G, Colombo, S, Quercioli, A, Barreca, A, Durante Mangoni, E, Pinto, D, Incasa, E, Rizzoli, E, Vanoli, M, Casella, G, Musca, G, Cuccurullo, O, Famularo, G, Sajeva, MR, Picardi, A, Hila, D, Rozzini, R, Giordano, A, Bonelli, A, Dentamaro, G, Gobbo, G, Cazzaniga, M, Gaudenzi, P, Giusto, L, Rizzoni, D, Castoldi, L, Mari, D, Micale, G, Altomare, E, Serviddio, G, Longhini, C, Molino, C, Deidda, S, Cuccuru, LM, Quagliolo, M, Centenaro, GR, Pasqui, AL, Puccetti, L, Bertolino, G, Cavallo, P, Bertolini, D, Liberato, NL, Perciccante, A, Coralli, A, Anastasio, L, Bertucci, L, Macura, A, Matino, D, Morabito, C, Fava, R, Di Sciacca, R, Semplicini, A, Magagnotti, G, Fiorentini, A, Tofi, C, Cagnoni, C, Manucra, A, Romanelli, G, Cortellaro, M, Meroni, MR, Rossi, DP, Vergani, C., CORRAO, Salvatore, TUTTOLOMONDO, Antonino |
| المساهمون: | Marcucci, M, Iorio, A, Nobili, A, Tettamanti, M, Pasina, L, Marengoni, A, Salerno, F, Corrao, S, Mannucci, PM, Tedeschi, A, Rossio, R, Moreo, G, Ferrari, B, Mammarella, A, Raparelli, V, Rondinella, S, Giannico, I, Rasciti, L, Gualandi, S, Monzani, V, Savojardo, V, Fabio, G, Colombo, S, Quercioli, A, Barreca, A, Durante-Mangoni, E, Pinto, D, Incasa, E, Rizzoli, E, Vanoli, M, Casella, G, Musca, G, Cuccurullo, O, Famularo, G, Sajeva, MR, Picardi, A, Hila, D, Rozzini, R, Giordano, A, Bonelli, A, Dentamaro, G, Gobbo, G, Cazzaniga, M, Gaudenzi, P, Giusto, L, Rizzoni, D, Castoldi, L, Mari, D, Micale, G, Altomare, E, Serviddio, G, Longhini, C, Molino, C, Deidda, S, Cuccuru, LM, Quagliolo, M, Centenaro, GR, Pasqui, AL, Puccetti, L, Bertolino, G, Cavallo, P, Bertolini, D, Liberato, NL, Perciccante, A, Coralli, A, Anastasio, L, Bertucci, L, Macura, A, Matino, D, Morabito, C, Fava, R, Tuttolomondo, A, Di Sciacca, R, Semplicini, A, Magagnotti, G, Fiorentini, A, Tofi, C, Cagnoni, C, Manucra, A, Romanelli, G, Cortellaro, M, Meroni, MR, Rossi, DP, Vergani, C |
| بيانات النشر: | Elsevier Science Limited |
| سنة النشر: | 2010 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | guideline, antithrombotic therapy, atrial fibrillation, Settore MED/09 - Medicina Interna |
| الوصف: | Current guidelines for ischemic stroke prevention in atrial fibrillation or flutter (AFF) recommend Vitamin K antagonists (VKAs) for patients at high-intermediate risk and aspirin for those at intermediate-low risk. The cost-effectiveness of these treatments was demonstrated also in elderly patients. However, there are several reports that emphasize the underuse of pharmacological prophylaxis of cardio-embolism in patients with AFF in different health care settings. AIMS: To evaluate the adherence to current guidelines on cardio-embolic prophylaxis in elderly (> 65 years old) patients admitted with an established diagnosis of AFF to the Italian internal medicine wards participating in REPOSI registry, a project on polypathologies/polytherapies stemming from the collaboration between the Italian Society of Internal Medicine and the Mario Negri Institute of Pharmacological Research; to investigate whether or not hospitalization had an impact on guidelines adherence; to test the role of possible modifiers of VKAs prescription. METHODS: We retrospectively analyzed registry data collected from January to December 2008 and assessed the prevalence of patients with AFF at admission and the prevalence of risk factors for cardio-embolism. After stratifying the patients according to their CHADS(2) score the percentage of appropriateness of antithrombotic therapy prescription was evaluated both at admission and at discharge. Univariable and multivariable logistic regression models were employed to verify whether or not socio-demographic (age >80years, living alone) and clinical features (previous or recent bleeding, cranio-facial trauma, cancer, dementia) modified the frequency and modalities of antithrombotic drugs prescription at admission and discharge. RESULTS: Among the 1332 REPOSI patients, 247 were admitted with AFF. At admission, CHADS(2) score was ≥ 2 in 68.4% of patients, at discharge in 75.9%. Among patients with AFF 26.5% at admission and 32.8% at discharge were not on any antithrombotic therapy, and 43.7% ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/21111937; info:eu-repo/semantics/altIdentifier/wos/WOS:000284625000009; volume:6; issue:21; firstpage:516-23.; lastpage:516; numberofpages:523; journal:EUROPEAN JOURNAL OF INTERNAL MEDICINE; http://hdl.handle.net/10447/75028Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-78649508381 |
| DOI: | 10.1016/j.ejim.2010.07.014 |
| الإتاحة: | https://doi.org/10.1016/j.ejim.2010.07.014Test http://hdl.handle.net/10447/75028Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.38BEB3AA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejim.2010.07.014 |
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