دورية أكاديمية
Alpha2-macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease
| العنوان: | Alpha2-macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease |
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| المؤلفون: | Nacmias, B, Tedde, A, Cellini, E, Forleo, P, Guarnieri, B, Petruzzi, C, D'Andrea, F, Serio, A, Sorbi, S., ORLACCHIO, ANTONIO |
| المساهمون: | Nacmias, B, Tedde, A, Cellini, E, Forleo, P, Orlacchio, A, Guarnieri, B, Petruzzi, C, D'Andrea, F, Serio, A, Sorbi, S |
| بيانات النشر: | Elsevier Science Ireland Limited |
| سنة النشر: | 2001 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Polymorphism, Genetic, Human, Alzheimer Disease, Aged, Apolipoproteins E, Italy, Genotype, Allele, alpha-Macroglobulin, Middle Aged, Mutation, Female, Male, Settore MED/26 - NEUROLOGIA |
| الوصف: | A 5-bp deletion and a Val1000 polymorphism at the alpha(2)-macroglobulin (A2M) gene have recently been reported to be associated with late onset Alzheimer's disease (AD). As recently it has been suggested that the effect of the A2M gene on AD susceptibility may be limited to certain populations or families, we analyzed the segregation of A2M and apolipoprotein E polymorphisms in Italian sporadic and familial AD. We analyzed the two polymorphisms in a total of 346 subjects including 98 controls by polymerase chain reaction-restriction fragment length polymorphism method. Our data do not confirm these associations, in particular we found a significant decrease of the deletion allele in AD with respect to controls. Our data do not support a role for the A2M gene as genetic risk factor for AD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/11166925; info:eu-repo/semantics/altIdentifier/wos/000166787900003; volume:299; issue:1-2; firstpage:9; lastpage:12; journal:NEUROSCIENCE LETTERS; http://hdl.handle.net/2108/90020Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0035895415 |
| DOI: | 10.1016/S0304-3940(00)01758-4 |
| الإتاحة: | https://doi.org/10.1016/S0304-3940Test(00)01758-4 http://hdl.handle.net/2108/90020Test |
| رقم الانضمام: | edsbas.B6D2AB79 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S0304-3940(00)01758-4 |
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