دورية أكاديمية
Alteration of cholinergic pressor and antinociceptive responses in rats pretreated with the cholinergic toxin AF64A
| العنوان: | Alteration of cholinergic pressor and antinociceptive responses in rats pretreated with the cholinergic toxin AF64A |
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| المساهمون: | Tellioglu, T, Erin, N, Akin, SB, Berkman, K, Oktay, S |
| بيانات النشر: | ELSEVIER SCIENCE INC |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | cholinergic control, blood pressure, antinociception, AF64A, Alzheimer's disease, physostigmine, oxotremorine, INTRAVENTRICULARLY ADMINISTERED ACETYLCHOLINE, MUSCARINIC RECEPTOR SUBTYPES, CENTRAL NERVOUS-SYSTEM, BLOOD-PRESSURE, HYPERTENSIVE RESPONSE, PASSIVE-AVOIDANCE, CENTRAL CARBACHOL, NEUROTOXIN AF64A, STIMULATION |
| الوصف: | 1. In the present study, the presser and antinociceptive effects of physostigmine and oxotremorine were investigated in rats injected with AF64A intracerebroventricularly. 2. Physostigmine (50-100 mu g/kg, IV)-induced presser responses were significantly lower in AF64A-injected rats compared with saline injected animals, whereas oxotremorine (20-80 mu g/kg, IV) induced responses were found to be similar to those seen in the saline group. 3. The physostigmine (100 mu g/kg, SC)-induced antinociceptive effect was totally abolished by AF64A treatment, but that of oxotremorine (30 mu g/kg, SC) remained unchanged at the tail-flick test. 4. The results of this study present functional evidence for AF64A-produced substantial loss of cholinergic neurons involved in the regulation of blood pressure and nociception but not in postsynaptic muscarinic receptors. (C) 1998 Elsevier Science Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0306-3623 |
| العلاقة: | GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM; 9522170; https://hdl.handle.net/11424/226639Test; WOS:000072281900014 |
| DOI: | 10.1016/S0306-3623(97)00298-X |
| الإتاحة: | https://doi.org/10.1016/S0306-3623Test(97)00298-X https://hdl.handle.net/11424/226639Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.6AB2D48C |
| قاعدة البيانات: | BASE |
| تدمد: | 03063623 |
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| DOI: | 10.1016/S0306-3623(97)00298-X |