دورية أكاديمية
The impact of survivorship bias in glioblastoma research
| العنوان: | The impact of survivorship bias in glioblastoma research |
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| المؤلفون: | Pasqualetti, Francesco, Barberis, Alessandro, Zanotti, Sofia, Montemurro, Nicola, De Salvo, Gian Luca, Soffietti, Riccardo, Mazzanti, Chiara Maria, Ius, Tamara, Caffo, Maria, Paiar, Fabiola, Bocci, Guido, Lombardi, Giuseppe, Harris, Adrian L, Buffa, Francesca M |
| المساهمون: | Pasqualetti, Francesco, Barberis, Alessandro, Zanotti, Sofia, Montemurro, Nicola, De Salvo, Gian Luca, Soffietti, Riccardo, Mazzanti, Chiara Maria, Ius, Tamara, Caffo, Maria, Paiar, Fabiola, Bocci, Guido, Lombardi, Giuseppe, Harris, Adrian L, Buffa, Francesca M |
| بيانات النشر: | ELSEVIER SCIENCE INC |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi di Messina: IRIS |
| مصطلحات موضوعية: | Biomarker, Glioblastoma, Liquid biopsy, Methodology, O6-methylguanine-DNA methyltransferase (MGMT) methylation, Research, Selection bia, Translational research |
| الوصف: | Despite advances in the therapy of Central Nervous System (CNS) malignancies, treatment of glioblastoma (GB) poses significant challenges due to GB resistance and high recurrence rates following post-operative radiochemotherapy. The majority of prognostic and predictive GB biomarkers are currently developed using tumour samples obtained through surgical interventions. However, the selection criteria adopted by different neurosurgeons to determine which cases are suitable for surgery make operated patients not representative of all GB cases. Particularly, geriatric and frail individuals are excluded from surgical consideration in some cancer centers. Such selection generates a survival (or selection) bias that introduces limitations, rendering the patients or data chosen for downstream analyses not representative of the entire community. In this review, we discuss the implication of survivorship bias on current and novel biomarkers for patient selection, stratification, therapy, and outcome analyses. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37392899; info:eu-repo/semantics/altIdentifier/wos/WOS:001054691000001; volume:188; firstpage:104065; lastpage:104070; numberofpages:6; journal:CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY; https://hdl.handle.net/11570/3274549Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85164437526 |
| DOI: | 10.1016/j.critrevonc.2023.104065 |
| الإتاحة: | https://doi.org/10.1016/j.critrevonc.2023.104065Test https://hdl.handle.net/11570/3274549Test |
| رقم الانضمام: | edsbas.F669619C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.critrevonc.2023.104065 |
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