Tempol, an intracelullar free radical scavenger, reduces liver injury in hepatic ischemia-reperfusion in the rat
| العنوان: | Tempol, an intracelullar free radical scavenger, reduces liver injury in hepatic ischemia-reperfusion in the rat |
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| المؤلفون: | Helder Mota-Filipe, Christoph Thiemermann, Michelle C. McDonald, Rui Pinto, Bruno Sepodes, J Mendes-do-Vale, C Marques, Rui Maio |
| المساهمون: | Repositório da Universidade de Lisboa |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| بيانات النشر: | ELSEVIER SCIENCE INC, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Male, Immunology, Ischemia, Pharmacology, Cyclic N-Oxides, chemistry.chemical_compound, Liver Function Tests, Lactate dehydrogenase, medicine, Animals, Rats, Wistar, chemistry.chemical_classification, Liver injury, Reactive oxygen species, Transplantation, Superoxide, Free Radical Scavengers, medicine.disease, Free radical scavenger, Rats, Disease Models, Animal, Liver, chemistry, Biochemistry, Reperfusion Injury, Spin Labels, Surgery, Liver function, Reactive Oxygen Species, Peroxynitrite |
| الوصف: | Liver ischemia is of clinical interest because of its role in liver failure and also hepatic graft rejection. The generation of reactive oxygen species contributes to the injury that follows ischemia-reperfusion. One therapy utilizes the administration of antioxidants; however, only limited experience suggests a potential benefit of systemic administration of these compounds. To overcome the limitations of these compounds, small molecules with improved cell membrane permeability characteristics and higher potency, such as tempol, are being tested in vivo. Tempol, a membrane-permeable radical scavenger, interferes with the formation or the effects of many radicals, including superoxide anions, hydroxyl radicals, and peroxynitrite. The aim of this study was to investigate the effects of tempol in an in vivo rat model of liver ischemia-reperfusion injury. Male Wistar rats were pretreated with tempol (30 mg/kg, i.v.) 5 minutes prior to liver ischemia (for 30 minutes) and reperfusion (for 2 hours). The liver injury was assessed by measuring serum levels of transaminases, lactate dehydrogenase, and gamma-glutamyl transferase. Tempol significantly mitigated the increase in transaminases, lactate dehydrogenase, and gamma-glutamyl transferase following liver ischemia-reperfusion, suggesting an improvement in liver function and resistance to injury. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61b83c892291e17c8e3b0f67ee1ab34Test https://hdl.handle.net/10451/21001Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f61b83c892291e17c8e3b0f67ee1ab34 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |