CSF1 expression in nongynecological leiomyosarcoma is associated with increased tumor angiogenesis
| العنوان: | CSF1 expression in nongynecological leiomyosarcoma is associated with increased tumor angiogenesis |
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| المؤلفون: | Espinosa I., Edris B., Lee C.-H., Cheng H.W., Gilks C.B., Wang Y., Montgomery K.D., Varma S., Li R., Marinelli R.J., West R.B., Nielsen T., Beck A.H., Van De Rijn M. |
| المصدر: | AMERICAN JOURNAL OF PATHOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| بيانات النشر: | ELSEVIER SCIENCE INC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Leiomyosarcoma, Male, cell infiltration, correlation analysis, Antigens, CD34, tumor associated leukocyte, preschool child, angiogenesis, Mice, primary tumor, CD34 antigen, Aged, 80 and over, child, Neovascularization, Pathologic, adult, article, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, aged, female, priority journal, Tumor Markers, Biological, soft tissue sarcoma, immunohistochemistry, isoprotein, microvasculature, Adolescent, animal experiment, Vascular Endoth, animal tissue, gene expression profiling, metastasis, Animals, Humans, controlled study, human, protein expression, mouse, nonhuman, vasculotropin, animal model, Macrophage Colony-Stimulating Factor, Macrophages, disease association, neovascularization (pathology), prediction, major clinical study, human tissue, tumor xenograft, antiangiogenic therapy, tumor marker, Microvessels, treatment outcome, colony stimulating factor 1, cell density |
| الوصف: | Leiomyosarcoma (LMS) is a malignant tumor of smooth muscle cells for which few effective therapies exist. A subset of LMS cases express macrophage colony-stimulating factor (CSF1) and the resultant tumor-associated macrophage (TAM) infiltration predicts poor clinical outcome. Further, TAMs have been shown to increase tumor angiogenesis. Here, we analyzed 149 LMS cases by immunohistochemistry for vascular marker CD34 and show that high microvessel density (MVD) in nongynecological LMS cases significantly predicts poor patient outcome. The majority of high MVD cases were also CSF1-positive, and when combining high MVD with CSF1 expression, an even stronger prognostic correlation with patient outcome was obtained. Gene expression profiling revealed that MVD has a stronger correlation with CSF1 expression than with expression of vascular endothelial growth factor isoforms, which have traditionally been used as markers of angiogenesis and as anti-angiogenic therapeutic targets. Finally, patterns of CSF1 expression and TAM recruitment remained consistent between primary tumors and their metastases, and between primary tumors and those grown as xenografts in mice, highlighting the stability of these features to the biology of LMS tumors. Together, these findings suggest an important role for CSF1 and the resulting TAM infiltration in the pathological neovascularization of LMS tumors and provide a rationale for CSF1-targeted therapies in LMS. © 2011 American Society for Investigative Pathology. |
| تدمد: | 0002-9440 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::b873702ee4b4da89c00b92c90d93fc1bTest https://www.scopus.com/inward/record.uri?eid=2-s2.0-80053229633&doi=10.1016/j.ajpath.2011.06.021&partnerID=40&md5=5a6be82a3a1c0053fab1d6b03fa57efbTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.RECOLECTA.....b873702ee4b4da89c00b92c90d93fc1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00029440 |
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