The Phenotype and Genotype of Congenital Myopathies Based on a Large Pediatric Cohort
| العنوان: | The Phenotype and Genotype of Congenital Myopathies Based on a Large Pediatric Cohort |
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| المؤلفون: | Loreto Martorell, Sergi Cesar, Daniel Cuadras, Cristina Jou, Jessica Expósito-Escudero, Daniel Natera-de Benito, A. Codina, Carlos Ortez, Cecilia Jimenez-Mallebrera, Pia Gallano, Delia Yubero, Andrés Nascimento, Laura Carrera-García, Francesc Palau, Jaume Colomer, Lidia Gonzalez-Quereda |
| المصدر: | PEDIATRIC NEUROLOGY r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| بيانات النشر: | ELSEVIER SCIENCE INC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Next-generation sequencing, Single Center, 0302 clinical medicine, Fibrosis, Medicine, Molecular genetics, Age of Onset, Child, Congenital myopathy, medicine.diagnostic_test, High-Throughput Nucleotide Sequencing, Phenotype, Neurology, Child, Preschool, Cohort, Female, Muscle biopsy, medicine.symptom, Myopathies, Structural, Congenital, Adult, medicine.medical_specialty, Adolescent, Genotype, Natural history, Scoliosis, Young Adult, 03 medical and health sciences, Developmental Neuroscience, 030225 pediatrics, Internal medicine, Humans, Muscle, Skeletal, Myopathy, Retrospective Studies, business.industry, Genetic heterogeneity, Infant, medicine.disease, Cross-Sectional Studies, Pediatrics, Perinatology and Child Health, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Background: Congenital myopathies (CMs) are a clinically and genetically heterogeneous group of hereditary muscular disorders. The distribution of genetic and histologic subtypes has been addressed in only a few cohorts, and the relationship between phenotypes and genotypes is only partially understood. Methods: This is a retrospective cross-sectional data collection study conducted at a single center. The clinical, histopathological, and molecular characterization of 104 patients with CM is reported. Results: The most common histopathological subtype was core myopathy (42%). Patients with severe endomysial fibrosis were more commonly unable to walk than patients with only a mild-grade endomysial fibrosis (56% vs 16%). Inability to walk was also more prevalent in patients with severe fatty replacement (44% vs 19%). The genetic etiology was more frequently identified among those patients with "specific" histologic findings (74% vs 62%). A definite molecular diagnosis was reached in 65 of 104 patients (62%), with RYR1 (24/104) and ITN (8/104) being the most frequent causative genes. Neonatal onset occurred in 56%. Independent ambulation was achieved by 74%. Patients who walked late were more likely to become wheelchair-dependent. Respiratory support was needed in one of three patients. Gastrostomy placement was required in 15%. Cardiac involvement was observed in 3%, scoliosis in 43%, and intellectual disability in 6%. Conclusions: This study provides an updated picture of the clinical, histopathological, and molecular landscape of CMs. Independently of the causative gene, fibrosis and fatty replacement in muscle biopsy specimens are associated with clinical severity. Mutations in TTN are responsible for a higher proportion of cases than previously thought. (C) 2020 Elsevier Inc. All rights reserved. |
| تدمد: | 0887-8994 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c89ae85b88c39ebcdb61b0d595ef6f7Test http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18651Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7c89ae85b88c39ebcdb61b0d595ef6f7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08878994 |
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