دورية أكاديمية
The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review
| العنوان: | The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review |
|---|---|
| المؤلفون: | La Rocca, G, Sabatino, G |
| المساهمون: | Monticelli, M, Zeppa, P, Zenga, F, Altieri, R, Mammi, M, Bertero, L, Castellano, I, Cassoni, P, Melcarne, A, La Rocca, Giuseppe, Sabatino, Giovanni, Ducati, A, Garbossa, D |
| بيانات النشر: | ELSEVIER SCIENCE BV |
| سنة النشر: | 2018 |
| المجموعة: | Università Cattolica del Sacro Cuore: PubliCatt |
| مصطلحات موضوعية: | Glioblastoma, MGMT, IDH1, IDH2, TERT, BRAE, High grade gliomas, Molecular biology, Settore MED/27 - NEUROCHIRURGIA |
| الوصف: | Glioblastoma (GBM) is the most common glioma in adults, with incidence increasing by 3% per year. According to the World Health Organization Classification of Central Nervous System Tumors, GBM is considered a grade IV tumor due to its malignant behavior.The aim of this review is to summarize the main biological aspects of GBM. In particular, we focused our attention on those alterations which have been proven to have an impact on patients' outcome, mainly in terms of overall survival (OS), or on the tumor response to therapies. We have also analyzed the cellular biology and the interactions between GBM and the surrounding environment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29777944; info:eu-repo/semantics/altIdentifier/wos/WOS:000435622600025; volume:170; issue:n.d; firstpage:120; lastpage:126; numberofpages:7; issueyear:2018; journal:CLINICAL NEUROLOGY AND NEUROSURGERY; http://hdl.handle.net/10807/172248Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85047090238 |
| DOI: | 10.1016/j.clineuro.2018.05.015 |
| الإتاحة: | https://doi.org/10.1016/j.clineuro.2018.05.015Test http://hdl.handle.net/10807/172248Test |
| رقم الانضمام: | edsbas.CC149407 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.clineuro.2018.05.015 |
|---|