دورية أكاديمية
Proteomic characterization in the hippocampus of prenatally stressed rats
| العنوان: | Proteomic characterization in the hippocampus of prenatally stressed rats |
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| المؤلفون: | MAIRESSE, JEROME, ZUENA, Anna Rita, NICOLETTI, Ferdinando, MACCARI, STEFANIA, A. s. Vercoutter Edouart, J. Marrocco, A. Giovine, J. c. Michalski, S. Morley Fletcher |
| المساهمون: | Mairesse, Jerome, A. s., Vercoutter Edouart, J., Marrocco, Zuena, Anna Rita, A., Giovine, Nicoletti, Ferdinando, J. c., Michalski, Maccari, Stefania, S., Morley Fletcher |
| بيانات النشر: | ELSEVIER SCIENCE BV |
| سنة النشر: | 2012 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | repressor protein, physical, animal, nerve tissue protein, transferrin, anxiety, metabolism, male, stre, psychological, animal model, sprague-dawley, early life stre, depression, programming, female, pregnancy, prenatal exposure delayed effect, hippocampu, restraint, proteomic, rat, microfilament protein, mood disorders |
| الوصف: | Rats exposed to early life stress are considered as a valuable model for the study of epigenetic programming leading to mood disorders and anxiety in the adult life. Rats submitted to prenatal restraint stress (PRS) are characterized by an anxious/depressive phenotype associated with neuroadaptive changes in the hippocampus. We used the model of PRS to identify proteins that are specifically affected by early life stress. We therefore performed a proteomic analysis in the hippocampus of adult male PRS rats. We found that PRS induced changes in the expression profile of a number of proteins, involved in the regulation of signal transduction, synaptic vesicles, protein synthesis, cytoskeleton dynamics, and energetic metabolism. Immunoblot analysis showed significant changes in the expression of proteins, such as LASP-1, fascin, and prohibitin, which may lie at the core of the developmental programming triggered by early life stress. (C) 2011 Elsevier B.V. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/22230806; info:eu-repo/semantics/altIdentifier/wos/WOS:000302038700007; volume:75; issue:6; firstpage:1764; lastpage:1770; numberofpages:7; journal:JOURNAL OF PROTEOMICS; http://hdl.handle.net/11573/469096Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84857652108; http://dx.doi.org/10.1016/j.jprot.2011.12.017Test; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000302038700007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest; http://www.scopus.com/inward/record.url?eid=2-s2.0-84857652108&partnerID=65&md5=6c3bcd7795c9e2e89d8944831ad1ba16Test |
| DOI: | 10.1016/j.jprot.2011.12.017 |
| الإتاحة: | https://doi.org/10.1016/j.jprot.2011.12.017Test http://hdl.handle.net/11573/469096Test http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000302038700007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest http://www.scopus.com/inward/record.url?eid=2-s2.0-84857652108&partnerID=65&md5=6c3bcd7795c9e2e89d8944831ad1ba16Test |
| رقم الانضمام: | edsbas.CE72C24F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jprot.2011.12.017 |
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