دورية أكاديمية
Specific isomyosin proportions in hyperexcitable and physiologically denervated mouse muscle
| العنوان: | Specific isomyosin proportions in hyperexcitable and physiologically denervated mouse muscle |
|---|---|
| المؤلفون: | Agbulut, O, Noirez, P, Butler-Browne, G, Jockusch, Harald |
| بيانات النشر: | ELSEVIER SCIENCE BV |
| سنة النشر: | 2004 |
| المجموعة: | PUB - Publications at Bielefeld University |
| مصطلحات موضوعية: | spinal muscular atrophy (wr, mto), myotonia (adr, high, muscular chloride channel ClC-1, resolution polyacrylamide gel electrophoresis, myosin heavy chain isoform, (mdx), muscular dystrophy, mdf) |
| الوصف: | Agbulut O, Noirez P, Butler-Browne G, Jockusch H. Specific isomyosin proportions in hyperexcitable and physiologically denervated mouse muscle. FEBS LETTERS . 2004;561(1-3):191-194. ; We show here, by high resolution sodium dodecyl sulfate gel electrophoresis, that the proportions of myosin heavy chain (MyHC) isoforms of mouse muscles are specifically shifted by hereditary neuromuscular diseases. In wild-type and dystrophic MDX anterior tibial muscle (TA) about 60% of the MyHC is IIB, 30% IIX, at most 10% IIA and < 2% type I (slow). In myotonic fast muscles, hyperexcitability leads to a drastic reduction of MyHC IIB which is compensated by IIA. Slow muscles, like soleus and diaphragm, were only marginally changed by myotonia. The MyHC pattern of TA of spinal muscular atrophy (SMA) 'wobbler' mice is shifted to a faster phenotype, with nearly 90% IIB. In the SMA mutant 'muscle deficient', all four adult isomyosins are expressed in the TA. These findings may be relevant for the future diagnosis of neurological disorders both in mouse disease models and in human patients. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/issn/0014-5793; info:eu-repo/semantics/altIdentifier/wos/000220244100034; info:eu-repo/semantics/altIdentifier/pmid/15013776; https://pub.uni-bielefeld.de/record/1608444Test |
| الإتاحة: | https://doi.org/10.1016/S0014-5793Test(04)00179-6 https://pub.uni-bielefeld.de/record/1608444Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.214051B8 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |