دورية أكاديمية
In relentless pursuit of the white whale: a role for the ventral midline thalamus in behavioral flexibility and adaption?
| العنوان: | In relentless pursuit of the white whale: a role for the ventral midline thalamus in behavioral flexibility and adaption? |
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| المؤلفون: | Panzer, Elodie, Guimares-Olmo, Isabella, de Vasconcelos, Anne Pereira, Stéphan, Aline, Cassel, Jean-Christophe |
| المصدر: | Neurosci Biobehav Rev ; ISSN:1873-7528 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Behavioral flexibility, Thalamus, extinction, nucleus reuniens, nucleus rhomboid, prefrontal cortex, reversal learning, set shifting |
| الوصف: | The reuniens (Re) nucleus is located in the ventral midline thalamus. It has fostered increasing interest, not only for its participation in a variety of cognitive functions (e.g., spatial working memory, systemic consolidation, reconsolidation, extinction of fear or generalization), but also for its neuroanatomical positioning as a bidirectional relay between the prefrontal cortex (PFC) and the hippocampus (HIP). In this review we compile and discuss recent studies having tackled a possible implication of the Re nucleus in behavioral flexibility, a major PFC-dependent executive function controlling goal-directed behaviors. Experiments considered explored a possible role for the Re nucleus in perseveration, reversal learning, fear extinction, and set-shifting. They point to a contribution of this nucleus to behavioral flexibility, mainly by its connections with the PFC, but possibly also by those with the hippocampus, and even with the amygdala, at least for fear-related behavior. As such, the Re nucleus could be a crucial crossroad supporting a PFC-orchestrated ability to cope with new, potentially unpredictable environmental contingencies, and thus behavioral flexibility and adaption. |
| نوع الوثيقة: | article in journal/newspaper review |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.neubiorev.2024.105762Test; https://pubmed.ncbi.nlm.nih.gov/38857666Test |
| DOI: | 10.1016/j.neubiorev.2024.105762 |
| الإتاحة: | https://doi.org/10.1016/j.neubiorev.2024.105762Test https://pubmed.ncbi.nlm.nih.gov/38857666Test |
| حقوق: | Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved. |
| رقم الانضمام: | edsbas.FEA16F25 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.neubiorev.2024.105762 |
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